Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study

Eyad Fawzi AlSaeed,1 Faisal Khalid Balaraj,2 Mutahir A Tunio3 1Department of Radiation Oncology, Faculty of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia; 2Al Faisal University, Chair of Radiation Oncology, Tawam Hospital, Al Ain, United Arab Emirates; 3Radiat...

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Autores principales:	AlSaeed EF, Balaraj FK, Tunio MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Breast carcinoma locoregional post mastectomy radiotherapy changes in pulmonary function tests Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8a37ab57fef24429bba1255a1a20a2b5
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spelling	oai:doaj.org-article:8a37ab57fef24429bba1255a1a20a2b52021-12-02T06:58:46ZChanges in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study1179-1314https://doaj.org/article/8a37ab57fef24429bba1255a1a20a2b52017-05-01T00:00:00Zhttps://www.dovepress.com/changes-in-pulmonary-function-tests-in-breast-carcinoma-patients-treat-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Eyad Fawzi AlSaeed,1 Faisal Khalid Balaraj,2 Mutahir A Tunio3 1Department of Radiation Oncology, Faculty of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia; 2Al Faisal University, Chair of Radiation Oncology, Tawam Hospital, Al Ain, United Arab Emirates; 3Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia Background: The aim of present pilot study was to evaluate the changes in pulmonary function tests (PFTs) after locoregional post-mastectomy radiotherapy (PMRT) in breast cancer patients. Materials and methods: Twenty consecutive patients with histopathologically confirmed breast carcinoma stages T1–T4, N1–N2, who were treated with modified radical mastectomy with neoadjuvant or adjuvant chemotherapy underwent PFTs, including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory flow at 50%, and peak expiratory flow rate, maximum mid expiratory flow (MMEF25–75), maximal oxygen consumption (VO2max), and carbon monoxide diffusing capacity (DLCO) before, at 30 days, and at 90 days after locoregional PMRT. A two-tailed paired Student’s t-test was used to compare mean values among the variables between the groups Results: A significant drop in FVC, FEV1, and DLCO was noticed at day 90 after the completion of locoregional PMRT with P-values 0.033, 0.042, and 0.031, respectively, while MMEF25–75 and VO2max were not significantly affected (P-values 0.075 and 0.062, respectively) favoring a restrictive lung injury pattern. However, no patient was found to be symptomatic. Conclusion: A significant drop in reduction in PFTs occurred at day 90 after the completion of locoregional PMRT. PFTs shall be performed in all breast cancer patients receiving locoregional PMRT for early detection of radiation-induced lung toxicity as all patients in our cohort were found asymptomatic. Keywords: breast carcinoma, locoregional, post-mastectomy radiotherapy, changes in pulmonary function testsAlSaeed EFBalaraj FKTunio MADove Medical PressarticleBreast carcinomalocoregionalpost mastectomy radiotherapychanges in pulmonary function testsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 375-381 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast carcinoma locoregional post mastectomy radiotherapy changes in pulmonary function tests Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast carcinoma locoregional post mastectomy radiotherapy changes in pulmonary function tests Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 AlSaeed EF Balaraj FK Tunio MA Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
description	Eyad Fawzi AlSaeed,1 Faisal Khalid Balaraj,2 Mutahir A Tunio3 1Department of Radiation Oncology, Faculty of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia; 2Al Faisal University, Chair of Radiation Oncology, Tawam Hospital, Al Ain, United Arab Emirates; 3Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia Background: The aim of present pilot study was to evaluate the changes in pulmonary function tests (PFTs) after locoregional post-mastectomy radiotherapy (PMRT) in breast cancer patients. Materials and methods: Twenty consecutive patients with histopathologically confirmed breast carcinoma stages T1–T4, N1–N2, who were treated with modified radical mastectomy with neoadjuvant or adjuvant chemotherapy underwent PFTs, including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory flow at 50%, and peak expiratory flow rate, maximum mid expiratory flow (MMEF25–75), maximal oxygen consumption (VO2max), and carbon monoxide diffusing capacity (DLCO) before, at 30 days, and at 90 days after locoregional PMRT. A two-tailed paired Student’s t-test was used to compare mean values among the variables between the groups Results: A significant drop in FVC, FEV1, and DLCO was noticed at day 90 after the completion of locoregional PMRT with P-values 0.033, 0.042, and 0.031, respectively, while MMEF25–75 and VO2max were not significantly affected (P-values 0.075 and 0.062, respectively) favoring a restrictive lung injury pattern. However, no patient was found to be symptomatic. Conclusion: A significant drop in reduction in PFTs occurred at day 90 after the completion of locoregional PMRT. PFTs shall be performed in all breast cancer patients receiving locoregional PMRT for early detection of radiation-induced lung toxicity as all patients in our cohort were found asymptomatic. Keywords: breast carcinoma, locoregional, post-mastectomy radiotherapy, changes in pulmonary function tests
format	article
author	AlSaeed EF Balaraj FK Tunio MA
author_facet	AlSaeed EF Balaraj FK Tunio MA
author_sort	AlSaeed EF
title	Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
title_short	Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
title_full	Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
title_fullStr	Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
title_full_unstemmed	Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
title_sort	changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8a37ab57fef24429bba1255a1a20a2b5
work_keys_str_mv	AT alsaeedef changesinpulmonaryfunctiontestsinbreastcarcinomapatientstreatedwithlocoregionalpostmastectomyradiotherapyresultsofapilotstudy AT balarajfk changesinpulmonaryfunctiontestsinbreastcarcinomapatientstreatedwithlocoregionalpostmastectomyradiotherapyresultsofapilotstudy AT tunioma changesinpulmonaryfunctiontestsinbreastcarcinomapatientstreatedwithlocoregionalpostmastectomyradiotherapyresultsofapilotstudy
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Changes in pulmonary function tests in breast carcinoma patients treated with locoregional post-mastectomy radiotherapy: results of a pilot study

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