Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma

Burak Turgut, Murat Kaya, Sermal Arslan, Tamer Demir, Mete Güler, Mehmet Kaan KayaFırat University School of Medicine, Department of Ophthalmology, Elazıg, TurkeyObjective: To compare the levels of plasma homocysteine (Hcy), vitamin B6 (vit-B6), serum vitamin B12 (vit-B12), and folate in he...

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Autores principales:	Burak Turgut, Murat Kaya, Sermal Arslan, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	normal tension glaucoma pseudoexfoliative glaucoma primary open angle glaucoma homocysteine vitamin B6. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8a388d0318e84164847ecb2dfa11a088
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spelling	oai:doaj.org-article:8a388d0318e84164847ecb2dfa11a0882021-12-02T00:07:42ZLevels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma1178-1998https://doaj.org/article/8a388d0318e84164847ecb2dfa11a0882010-04-01T00:00:00Zhttps://www.dovepress.com/levels-of-circulating-homocysteine-vitamin-b6-vitamin-b12-and-folate-i-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Burak Turgut, Murat Kaya, Sermal Arslan, Tamer Demir, Mete Güler, Mehmet Kaan KayaFırat University School of Medicine, Department of Ophthalmology, Elazıg, TurkeyObjective: To compare the levels of plasma homocysteine (Hcy), vitamin B6 (vit-B6), serum vitamin B12 (vit-B12), and folate in healthy individuals and in patients with normal tension glaucoma (NTG), pseudoexfoliative glaucoma (PXG), or primary open-angle glaucoma (POAG).Study design: A prospective controlled trial.Participants and methods: Forty healthy subjects, 48 patients with NTG, 38 patients with PXG, and 34 patients with POAG were included in the study. Those who used vitamin supplements or medications affecting Hcy and vitamin levels were excluded from the study. The levels of Hcy and vit-B6 were measured by High Performance Liquid Chromatography (HPLC). The levels of serum vit-B12 and folic acid were measured by competitive chemiluminescent enzyme immunoassay (CEI). One-way analysis if variance (ANOVA), analysis of covariance (ANCOVA), and the Tukey honestly significant difference test were used for statistical analysis.Results: The mean Hcy level of the PXG group was 15.46 ± 9.27 μmol/L which was significantly higher (P = 0.03) than that of the control group. There were no statistical differences in serum vit-B12 and folate levels among control subjects and NTG, PXG and POAG groups (P > 0.05). It was found that the mean plasma vit-B6 level was significantly higher in subjects with NTG (P = 0.03) and POAG (P = 0.025) versus controls. Mean vit-B6 levels in NTG and POAG were 30.50 ± 11.29 μg/L and 30 ± 12.15 μg/L, respectively.Conclusions: The plasma level of Hcy was found to be increased only in PXG patients and the plasma levels of vit-B6 were found to increase in the NTG and POAG sample groups. Using homocysteine and vit-B6 levels as the determinants of hyperhomocysteinemia still needs further research.Keywords: normal tension glaucoma, pseudoexfoliative glaucoma, primary open-angle glaucoma, homocysteine, vitamin B6Burak TurgutMurat KayaSermal Arslanet alDove Medical Pressarticlenormal tension glaucomapseudoexfoliative glaucomaprimary open angle glaucomahomocysteinevitamin B6.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 5, Pp 133-139 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	normal tension glaucoma pseudoexfoliative glaucoma primary open angle glaucoma homocysteine vitamin B6. Geriatrics RC952-954.6
spellingShingle	normal tension glaucoma pseudoexfoliative glaucoma primary open angle glaucoma homocysteine vitamin B6. Geriatrics RC952-954.6 Burak Turgut Murat Kaya Sermal Arslan et al Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
description	Burak Turgut, Murat Kaya, Sermal Arslan, Tamer Demir, Mete Güler, Mehmet Kaan KayaFırat University School of Medicine, Department of Ophthalmology, Elazıg, TurkeyObjective: To compare the levels of plasma homocysteine (Hcy), vitamin B6 (vit-B6), serum vitamin B12 (vit-B12), and folate in healthy individuals and in patients with normal tension glaucoma (NTG), pseudoexfoliative glaucoma (PXG), or primary open-angle glaucoma (POAG).Study design: A prospective controlled trial.Participants and methods: Forty healthy subjects, 48 patients with NTG, 38 patients with PXG, and 34 patients with POAG were included in the study. Those who used vitamin supplements or medications affecting Hcy and vitamin levels were excluded from the study. The levels of Hcy and vit-B6 were measured by High Performance Liquid Chromatography (HPLC). The levels of serum vit-B12 and folic acid were measured by competitive chemiluminescent enzyme immunoassay (CEI). One-way analysis if variance (ANOVA), analysis of covariance (ANCOVA), and the Tukey honestly significant difference test were used for statistical analysis.Results: The mean Hcy level of the PXG group was 15.46 ± 9.27 μmol/L which was significantly higher (P = 0.03) than that of the control group. There were no statistical differences in serum vit-B12 and folate levels among control subjects and NTG, PXG and POAG groups (P > 0.05). It was found that the mean plasma vit-B6 level was significantly higher in subjects with NTG (P = 0.03) and POAG (P = 0.025) versus controls. Mean vit-B6 levels in NTG and POAG were 30.50 ± 11.29 μg/L and 30 ± 12.15 μg/L, respectively.Conclusions: The plasma level of Hcy was found to be increased only in PXG patients and the plasma levels of vit-B6 were found to increase in the NTG and POAG sample groups. Using homocysteine and vit-B6 levels as the determinants of hyperhomocysteinemia still needs further research.Keywords: normal tension glaucoma, pseudoexfoliative glaucoma, primary open-angle glaucoma, homocysteine, vitamin B6
format	article
author	Burak Turgut Murat Kaya Sermal Arslan et al
author_facet	Burak Turgut Murat Kaya Sermal Arslan et al
author_sort	Burak Turgut
title	Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
title_short	Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
title_full	Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
title_fullStr	Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
title_full_unstemmed	Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma
title_sort	levels of circulating homocysteine, vitamin b6, vitamin b12, and folate in different types of open-angle glaucoma
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/8a388d0318e84164847ecb2dfa11a088
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Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma

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