Infants with congenital heart defects have reduced brain volumes

Abstract Children with congenital heart defects (CHDs) have increased risk of cognitive disabilities for reasons not fully understood. Previous studies have indicated signs of disrupted fetal brain growth from mid-gestation measured with ultrasound and magnetic resonance imaging (MRI) and infants wi...

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Autores principales:	Mikkel B. Skotting, S. F. Eskildsen, A. S. Ovesen, V. S. Fonov, S. Ringgaard, V. E. Hjortdal, M. H. Lauridsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a3915c149ee4073b9cbd827829c70e4
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spelling	oai:doaj.org-article:8a3915c149ee4073b9cbd827829c70e42021-12-02T14:03:59ZInfants with congenital heart defects have reduced brain volumes10.1038/s41598-021-83690-32045-2322https://doaj.org/article/8a3915c149ee4073b9cbd827829c70e42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83690-3https://doaj.org/toc/2045-2322Abstract Children with congenital heart defects (CHDs) have increased risk of cognitive disabilities for reasons not fully understood. Previous studies have indicated signs of disrupted fetal brain growth from mid-gestation measured with ultrasound and magnetic resonance imaging (MRI) and infants with CHDs have decreased brain volumes at birth. We measured the total and regional brain volumes of infants with and without CHDs using MRI to investigate, if certain areas of the brain are at particular risk of disrupted growth. MRI brain volumetry analyses were performed on 20 infants; 10 with- (postmenstrual age 39–54 weeks, mean 44 weeks + 5 days) and 10 without CHDs (postmenstrual age 39–52 weeks, mean 43 weeks + 5 days). In six infants with- and eight infants without CHDs grey and white matter were also differentiated. Infants with CHDs had smaller brains (48 ml smaller; 95% CI, 6.1–90; p = 0.03), cerebrums (37.8 ml smaller; 95% CI, 0.8–74.8; p = 0.04), and cerebral grey matter (25.8 ml smaller; 95% CI, 3.5–48; p = 0.03) than infants without CHD. Brain volume differences observed within weeks after birth in children with CHDs confirm that the brain impact, which increase the risk of cognitive disabilities, may begin during pregnancy.Mikkel B. SkottingS. F. EskildsenA. S. OvesenV. S. FonovS. RinggaardV. E. HjortdalM. H. LauridsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mikkel B. Skotting S. F. Eskildsen A. S. Ovesen V. S. Fonov S. Ringgaard V. E. Hjortdal M. H. Lauridsen Infants with congenital heart defects have reduced brain volumes
description	Abstract Children with congenital heart defects (CHDs) have increased risk of cognitive disabilities for reasons not fully understood. Previous studies have indicated signs of disrupted fetal brain growth from mid-gestation measured with ultrasound and magnetic resonance imaging (MRI) and infants with CHDs have decreased brain volumes at birth. We measured the total and regional brain volumes of infants with and without CHDs using MRI to investigate, if certain areas of the brain are at particular risk of disrupted growth. MRI brain volumetry analyses were performed on 20 infants; 10 with- (postmenstrual age 39–54 weeks, mean 44 weeks + 5 days) and 10 without CHDs (postmenstrual age 39–52 weeks, mean 43 weeks + 5 days). In six infants with- and eight infants without CHDs grey and white matter were also differentiated. Infants with CHDs had smaller brains (48 ml smaller; 95% CI, 6.1–90; p = 0.03), cerebrums (37.8 ml smaller; 95% CI, 0.8–74.8; p = 0.04), and cerebral grey matter (25.8 ml smaller; 95% CI, 3.5–48; p = 0.03) than infants without CHD. Brain volume differences observed within weeks after birth in children with CHDs confirm that the brain impact, which increase the risk of cognitive disabilities, may begin during pregnancy.
format	article
author	Mikkel B. Skotting S. F. Eskildsen A. S. Ovesen V. S. Fonov S. Ringgaard V. E. Hjortdal M. H. Lauridsen
author_facet	Mikkel B. Skotting S. F. Eskildsen A. S. Ovesen V. S. Fonov S. Ringgaard V. E. Hjortdal M. H. Lauridsen
author_sort	Mikkel B. Skotting
title	Infants with congenital heart defects have reduced brain volumes
title_short	Infants with congenital heart defects have reduced brain volumes
title_full	Infants with congenital heart defects have reduced brain volumes
title_fullStr	Infants with congenital heart defects have reduced brain volumes
title_full_unstemmed	Infants with congenital heart defects have reduced brain volumes
title_sort	infants with congenital heart defects have reduced brain volumes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a3915c149ee4073b9cbd827829c70e4
work_keys_str_mv	AT mikkelbskotting infantswithcongenitalheartdefectshavereducedbrainvolumes AT sfeskildsen infantswithcongenitalheartdefectshavereducedbrainvolumes AT asovesen infantswithcongenitalheartdefectshavereducedbrainvolumes AT vsfonov infantswithcongenitalheartdefectshavereducedbrainvolumes AT sringgaard infantswithcongenitalheartdefectshavereducedbrainvolumes AT vehjortdal infantswithcongenitalheartdefectshavereducedbrainvolumes AT mhlauridsen infantswithcongenitalheartdefectshavereducedbrainvolumes
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Infants with congenital heart defects have reduced brain volumes

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