A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis

Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exempl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hena Khatoon, Emilia Abdulmalek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Lawesson’s reagent organic synthesis thio analogs biological applications Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/8a39dc350e6142b2b5bc44d067fb0464
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a39dc350e6142b2b5bc44d067fb0464
record_format	dspace
spelling	oai:doaj.org-article:8a39dc350e6142b2b5bc44d067fb04642021-11-25T18:28:34ZA Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis10.3390/molecules262269371420-3049https://doaj.org/article/8a39dc350e6142b2b5bc44d067fb04642021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6937https://doaj.org/toc/1420-3049Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exemplary results. However, the role of Lawesson’s reagent in synthesis has changed drastically, and now its use can help the chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, and the thionation of natural compounds. The ease of availability and the convenient usage of LR as a thionating agent made us compile a review on the new diverse applications on some common functional groups, such as ketones, esters, amides, alcohols, and carboxylic acids, with biological applications. Since the applications of LR are now diverse, we have also included some new classes of heterocycles such as thiazepines, phosphine sulfides, thiophenes, and organothiophosphorus compounds. Thionation of some biologically essential steroids and terpenoids has also been compiled. This review discusses the recent insights into and synthetic applications of this famous reagent from 2009 to January 2021.Hena KhatoonEmilia AbdulmalekMDPI AGarticleLawesson’s reagentorganic synthesisthio analogsbiological applicationsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6937, p 6937 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lawesson’s reagent organic synthesis thio analogs biological applications Organic chemistry QD241-441
spellingShingle	Lawesson’s reagent organic synthesis thio analogs biological applications Organic chemistry QD241-441 Hena Khatoon Emilia Abdulmalek A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
description	Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exemplary results. However, the role of Lawesson’s reagent in synthesis has changed drastically, and now its use can help the chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, and the thionation of natural compounds. The ease of availability and the convenient usage of LR as a thionating agent made us compile a review on the new diverse applications on some common functional groups, such as ketones, esters, amides, alcohols, and carboxylic acids, with biological applications. Since the applications of LR are now diverse, we have also included some new classes of heterocycles such as thiazepines, phosphine sulfides, thiophenes, and organothiophosphorus compounds. Thionation of some biologically essential steroids and terpenoids has also been compiled. This review discusses the recent insights into and synthetic applications of this famous reagent from 2009 to January 2021.
format	article
author	Hena Khatoon Emilia Abdulmalek
author_facet	Hena Khatoon Emilia Abdulmalek
author_sort	Hena Khatoon
title	A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
title_short	A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
title_full	A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
title_fullStr	A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
title_full_unstemmed	A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
title_sort	focused review of synthetic applications of lawesson’s reagent in organic synthesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8a39dc350e6142b2b5bc44d067fb0464
work_keys_str_mv	AT henakhatoon afocusedreviewofsyntheticapplicationsoflawessonsreagentinorganicsynthesis AT emiliaabdulmalek afocusedreviewofsyntheticapplicationsoflawessonsreagentinorganicsynthesis AT henakhatoon focusedreviewofsyntheticapplicationsoflawessonsreagentinorganicsynthesis AT emiliaabdulmalek focusedreviewofsyntheticapplicationsoflawessonsreagentinorganicsynthesis
_version_	1718411088584769536

A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis

Ejemplares similares