A somatic proteoglycan controls Notch-directed germ cell fate

Notch receptor GLP-1 is required for maintaining germ cells in the C. elegans germline. Here the authors show that syndecan-1, a somatic transmembrane proteoglycan regulates expression of glp-1 and germ cell mitosis in C. elegans, by promoting calcium-dependent binding of APTF-2 to the glp-1 promote...

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Autores principales:	Sandeep Gopal, Aqilah Amran, Andre Elton, Leelee Ng, Roger Pocock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a435783a66f4f3b95718b3624c44698
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spelling	oai:doaj.org-article:8a435783a66f4f3b95718b3624c446982021-11-21T12:35:35ZA somatic proteoglycan controls Notch-directed germ cell fate10.1038/s41467-021-27039-42041-1723https://doaj.org/article/8a435783a66f4f3b95718b3624c446982021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27039-4https://doaj.org/toc/2041-1723Notch receptor GLP-1 is required for maintaining germ cells in the C. elegans germline. Here the authors show that syndecan-1, a somatic transmembrane proteoglycan regulates expression of glp-1 and germ cell mitosis in C. elegans, by promoting calcium-dependent binding of APTF-2 to the glp-1 promoter.Sandeep GopalAqilah AmranAndre EltonLeelee NgRoger PocockNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandeep Gopal Aqilah Amran Andre Elton Leelee Ng Roger Pocock A somatic proteoglycan controls Notch-directed germ cell fate
description	Notch receptor GLP-1 is required for maintaining germ cells in the C. elegans germline. Here the authors show that syndecan-1, a somatic transmembrane proteoglycan regulates expression of glp-1 and germ cell mitosis in C. elegans, by promoting calcium-dependent binding of APTF-2 to the glp-1 promoter.
format	article
author	Sandeep Gopal Aqilah Amran Andre Elton Leelee Ng Roger Pocock
author_facet	Sandeep Gopal Aqilah Amran Andre Elton Leelee Ng Roger Pocock
author_sort	Sandeep Gopal
title	A somatic proteoglycan controls Notch-directed germ cell fate
title_short	A somatic proteoglycan controls Notch-directed germ cell fate
title_full	A somatic proteoglycan controls Notch-directed germ cell fate
title_fullStr	A somatic proteoglycan controls Notch-directed germ cell fate
title_full_unstemmed	A somatic proteoglycan controls Notch-directed germ cell fate
title_sort	somatic proteoglycan controls notch-directed germ cell fate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a435783a66f4f3b95718b3624c44698
work_keys_str_mv	AT sandeepgopal asomaticproteoglycancontrolsnotchdirectedgermcellfate AT aqilahamran asomaticproteoglycancontrolsnotchdirectedgermcellfate AT andreelton asomaticproteoglycancontrolsnotchdirectedgermcellfate AT leeleeng asomaticproteoglycancontrolsnotchdirectedgermcellfate AT rogerpocock asomaticproteoglycancontrolsnotchdirectedgermcellfate AT sandeepgopal somaticproteoglycancontrolsnotchdirectedgermcellfate AT aqilahamran somaticproteoglycancontrolsnotchdirectedgermcellfate AT andreelton somaticproteoglycancontrolsnotchdirectedgermcellfate AT leeleeng somaticproteoglycancontrolsnotchdirectedgermcellfate AT rogerpocock somaticproteoglycancontrolsnotchdirectedgermcellfate
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A somatic proteoglycan controls Notch-directed germ cell fate

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