Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial

Davood Soleimani,1 Zamzam Paknahad,2 Mohammad Hossein Rouhani3 1Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University...

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Autores principales:	Soleimani D, Paknahad Z, Rouhani MH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	allium sativum garlic hepatic steatosis nonalcoholic fatty liver disease Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8a4567e45e504d4796f18ea25186bb8b
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spelling	oai:doaj.org-article:8a4567e45e504d4796f18ea25186bb8b2021-12-02T09:31:10ZTherapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial1178-7007https://doaj.org/article/8a4567e45e504d4796f18ea25186bb8b2020-07-01T00:00:00Zhttps://www.dovepress.com/therapeutic-effects-of-garlic-on-hepatic-steatosis-in-nonalcoholic-fat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Davood Soleimani,1 Zamzam Paknahad,2 Mohammad Hossein Rouhani3 1Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; 3Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IranCorrespondence: Zamzam Paknahad Tel +98 3137923166Fax +98 3136681378Email Paknahad@hlth.mui.ac.irBackground and Aims: Emerging evidence suggests that garlic (Allium sativum L.) and its bioactive components can mitigate hepatic steatosis by the modulation of hepatic lipid metabolism. We aimed to assess the efficacy of the garlic administration on hepatic steatosis in patients with NAFLD.Patients and Methods: This clinical trial was conducted on adult patients with ultrasound-diagnosed NAFLD. Eligible participants were randomly assigned, with the use of the stratified blocked procedure, to receive 800 mg garlic or placebo for 15 weeks. The primary outcome was the improvement in the hepatic steatosis diagnosed by ultrasound technique after 15 weeks of intervention.Results: A total of 110 patients underwent randomization, and 98 patients completed the trial. Twenty-four (51.1%) patients in the garlic group achieved improvement in the hepatic steatosis compared to eight (15.7%) patients in the placebo group with the relative risk of 5.6 (95% CI: 2.17 to 14.5; P=0.001), which remained significant after adjusting for baseline value of hepatic steatosis. There were significant reductions in weight and serum ALT, AST, FBS, Hb A1C, total cholesterol, LDL-cholesterol, and TG concentration with the garlic intake compared to placebo (P< 0.05). The results were also significant after adjusting for weight change, energy intake, and physical activity. No serious adverse effects were observed with the garlic intake.Conclusion: The intake of garlic powder was accompanied by a significant improvement in the hepatic steatosis and comorbidity related to this condition among subjects with NAFLD.Keywords: Allium sativum, garlic, hepatic steatosis, nonalcoholic fatty liver diseaseSoleimani DPaknahad ZRouhani MHDove Medical Pressarticleallium sativumgarlichepatic steatosisnonalcoholic fatty liver diseaseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2389-2397 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	allium sativum garlic hepatic steatosis nonalcoholic fatty liver disease Specialties of internal medicine RC581-951
spellingShingle	allium sativum garlic hepatic steatosis nonalcoholic fatty liver disease Specialties of internal medicine RC581-951 Soleimani D Paknahad Z Rouhani MH Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial
description	Davood Soleimani,1 Zamzam Paknahad,2 Mohammad Hossein Rouhani3 1Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; 3Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IranCorrespondence: Zamzam Paknahad Tel +98 3137923166Fax +98 3136681378Email Paknahad@hlth.mui.ac.irBackground and Aims: Emerging evidence suggests that garlic (Allium sativum L.) and its bioactive components can mitigate hepatic steatosis by the modulation of hepatic lipid metabolism. We aimed to assess the efficacy of the garlic administration on hepatic steatosis in patients with NAFLD.Patients and Methods: This clinical trial was conducted on adult patients with ultrasound-diagnosed NAFLD. Eligible participants were randomly assigned, with the use of the stratified blocked procedure, to receive 800 mg garlic or placebo for 15 weeks. The primary outcome was the improvement in the hepatic steatosis diagnosed by ultrasound technique after 15 weeks of intervention.Results: A total of 110 patients underwent randomization, and 98 patients completed the trial. Twenty-four (51.1%) patients in the garlic group achieved improvement in the hepatic steatosis compared to eight (15.7%) patients in the placebo group with the relative risk of 5.6 (95% CI: 2.17 to 14.5; P=0.001), which remained significant after adjusting for baseline value of hepatic steatosis. There were significant reductions in weight and serum ALT, AST, FBS, Hb A1C, total cholesterol, LDL-cholesterol, and TG concentration with the garlic intake compared to placebo (P< 0.05). The results were also significant after adjusting for weight change, energy intake, and physical activity. No serious adverse effects were observed with the garlic intake.Conclusion: The intake of garlic powder was accompanied by a significant improvement in the hepatic steatosis and comorbidity related to this condition among subjects with NAFLD.Keywords: Allium sativum, garlic, hepatic steatosis, nonalcoholic fatty liver disease
format	article
author	Soleimani D Paknahad Z Rouhani MH
author_facet	Soleimani D Paknahad Z Rouhani MH
author_sort	Soleimani D
title	Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial
title_short	Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial
title_full	Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial
title_fullStr	Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial
title_full_unstemmed	Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial
title_sort	therapeutic effects of garlic on hepatic steatosis in nonalcoholic fatty liver disease patients: a randomized clinical trial
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8a4567e45e504d4796f18ea25186bb8b
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Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial

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