Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors

In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate...

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Autores principales:	Ji-Yul Kim, Dae-Won Ki, Yoon-Ju Lee, Lee Su Ha, E-Eum Woo, In-Kyoung Lee, Bong-Sik Yun
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	consoramides a–c irpex consors nmr zwitterionic alkaloids Botany QK1-989
Acceso en línea:	https://doaj.org/article/8a45fbdcc15f4f50a49bac3f1af7d377
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spelling	oai:doaj.org-article:8a45fbdcc15f4f50a49bac3f1af7d3772021-12-01T14:40:58ZConsoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors1229-80932092-932310.1080/12298093.2021.1924926https://doaj.org/article/8a45fbdcc15f4f50a49bac3f1af7d3772021-07-01T00:00:00Zhttp://dx.doi.org/10.1080/12298093.2021.1924926https://doaj.org/toc/1229-8093https://doaj.org/toc/2092-9323In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C18 cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A–C (1-3).Ji-Yul KimDae-Won KiYoon-Ju LeeLee Su HaE-Eum WooIn-Kyoung LeeBong-Sik YunTaylor & Francis Grouparticleconsoramides a–cirpex consorsnmrzwitterionic alkaloidsBotanyQK1-989ENMycobiology, Vol 49, Iss 4, Pp 434-437 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	consoramides a–c irpex consors nmr zwitterionic alkaloids Botany QK1-989
spellingShingle	consoramides a–c irpex consors nmr zwitterionic alkaloids Botany QK1-989 Ji-Yul Kim Dae-Won Ki Yoon-Ju Lee Lee Su Ha E-Eum Woo In-Kyoung Lee Bong-Sik Yun Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
description	In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C18 cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A–C (1-3).
format	article
author	Ji-Yul Kim Dae-Won Ki Yoon-Ju Lee Lee Su Ha E-Eum Woo In-Kyoung Lee Bong-Sik Yun
author_facet	Ji-Yul Kim Dae-Won Ki Yoon-Ju Lee Lee Su Ha E-Eum Woo In-Kyoung Lee Bong-Sik Yun
author_sort	Ji-Yul Kim
title	Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_short	Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_full	Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_fullStr	Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_full_unstemmed	Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
title_sort	consoramides a–c, new zwitterionic alkaloids from the fungus irpex consors
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/8a45fbdcc15f4f50a49bac3f1af7d377
work_keys_str_mv	AT jiyulkim consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors AT daewonki consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors AT yoonjulee consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors AT leesuha consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors AT eeumwoo consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors AT inkyounglee consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors AT bongsikyun consoramidesacnewzwitterionicalkaloidsfromthefungusirpexconsors
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Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors

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