Biological age in healthy elderly predicts aging-related diseases including dementia

Abstract Application of biological age as a measure of an individual´s health status offers new perspectives into extension of both lifespan and healthspan. While algorithms predicting mortality and most aging-related morbidities have been reported, the major shortcoming has been an inability to pre...

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Autores principales:	Julia W. Wu, Amber Yaqub, Yuan Ma, Wouter Koudstaal, Albert Hofman, M. Arfan Ikram, Mohsen Ghanbari, Jaap Goudsmit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a4784fa5b184545b3e5fc85ad14cfce
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spelling	oai:doaj.org-article:8a4784fa5b184545b3e5fc85ad14cfce2021-12-02T14:53:34ZBiological age in healthy elderly predicts aging-related diseases including dementia10.1038/s41598-021-95425-52045-2322https://doaj.org/article/8a4784fa5b184545b3e5fc85ad14cfce2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95425-5https://doaj.org/toc/2045-2322Abstract Application of biological age as a measure of an individual´s health status offers new perspectives into extension of both lifespan and healthspan. While algorithms predicting mortality and most aging-related morbidities have been reported, the major shortcoming has been an inability to predict dementia. We present a community-based cohort study of 1930 participants with a mean age of 72 years and a follow-up period of over 7 years, using two variants of a phenotypic blood-based algorithm that either excludes (BioAge1) or includes (BioAge2) neurofilament light chain (NfL) as a neurodegenerative marker. BioAge1 and BioAge2 predict dementia equally well, as well as lifespan and healthspan. Each one-year increase in BioAge1/2 was associated with 11% elevated risk (HR 1.11; 95%CI 1.08–1.14) of mortality and 7% elevated risk (HR 1.07; 95%CI 1.05–1.09) of first morbidities. We additionally tested the association of microRNAs with age and identified 263 microRNAs significantly associated with biological and chronological age alike. Top differentially expressed microRNAs based on biological age had a higher significance level than those based on chronological age, suggesting that biological age captures aspects of aging signals at the epigenetic level. We conclude that accelerated biological age for a given age is a predictor of major age-related morbidity, including dementia, among healthy elderly.Julia W. WuAmber YaqubYuan MaWouter KoudstaalAlbert HofmanM. Arfan IkramMohsen GhanbariJaap GoudsmitNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia W. Wu Amber Yaqub Yuan Ma Wouter Koudstaal Albert Hofman M. Arfan Ikram Mohsen Ghanbari Jaap Goudsmit Biological age in healthy elderly predicts aging-related diseases including dementia
description	Abstract Application of biological age as a measure of an individual´s health status offers new perspectives into extension of both lifespan and healthspan. While algorithms predicting mortality and most aging-related morbidities have been reported, the major shortcoming has been an inability to predict dementia. We present a community-based cohort study of 1930 participants with a mean age of 72 years and a follow-up period of over 7 years, using two variants of a phenotypic blood-based algorithm that either excludes (BioAge1) or includes (BioAge2) neurofilament light chain (NfL) as a neurodegenerative marker. BioAge1 and BioAge2 predict dementia equally well, as well as lifespan and healthspan. Each one-year increase in BioAge1/2 was associated with 11% elevated risk (HR 1.11; 95%CI 1.08–1.14) of mortality and 7% elevated risk (HR 1.07; 95%CI 1.05–1.09) of first morbidities. We additionally tested the association of microRNAs with age and identified 263 microRNAs significantly associated with biological and chronological age alike. Top differentially expressed microRNAs based on biological age had a higher significance level than those based on chronological age, suggesting that biological age captures aspects of aging signals at the epigenetic level. We conclude that accelerated biological age for a given age is a predictor of major age-related morbidity, including dementia, among healthy elderly.
format	article
author	Julia W. Wu Amber Yaqub Yuan Ma Wouter Koudstaal Albert Hofman M. Arfan Ikram Mohsen Ghanbari Jaap Goudsmit
author_facet	Julia W. Wu Amber Yaqub Yuan Ma Wouter Koudstaal Albert Hofman M. Arfan Ikram Mohsen Ghanbari Jaap Goudsmit
author_sort	Julia W. Wu
title	Biological age in healthy elderly predicts aging-related diseases including dementia
title_short	Biological age in healthy elderly predicts aging-related diseases including dementia
title_full	Biological age in healthy elderly predicts aging-related diseases including dementia
title_fullStr	Biological age in healthy elderly predicts aging-related diseases including dementia
title_full_unstemmed	Biological age in healthy elderly predicts aging-related diseases including dementia
title_sort	biological age in healthy elderly predicts aging-related diseases including dementia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a4784fa5b184545b3e5fc85ad14cfce
work_keys_str_mv	AT juliawwu biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT amberyaqub biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT yuanma biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT wouterkoudstaal biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT alberthofman biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT marfanikram biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT mohsenghanbari biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia AT jaapgoudsmit biologicalageinhealthyelderlypredictsagingrelateddiseasesincludingdementia
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Biological age in healthy elderly predicts aging-related diseases including dementia

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