Mode of action of teixobactins in cellular membranes

The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind to Lipid II in anionic cellular membranes.

Guardado en:

Detalles Bibliográficos
Autores principales:	Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a53feac384048deba131cc874db54f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a53feac384048deba131cc874db54f3
record_format	dspace
spelling	oai:doaj.org-article:8a53feac384048deba131cc874db54f32021-12-02T17:51:04ZMode of action of teixobactins in cellular membranes10.1038/s41467-020-16600-22041-1723https://doaj.org/article/8a53feac384048deba131cc874db54f32020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16600-2https://doaj.org/toc/2041-1723The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind to Lipid II in anionic cellular membranes.Rhythm ShuklaJoão Medeiros-SilvaAnish ParmarBram J. A. VermeulenSanjit DasAlessandra Lucini PaioniShehrazade JekhmaneJoseph LorentAlexandre M. J. J. BonvinMarc BaldusMoreno LelliEdwin J. A. VeldhuizenEefjan BreukinkIshwar SinghMarkus WeingarthNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rhythm Shukla João Medeiros-Silva Anish Parmar Bram J. A. Vermeulen Sanjit Das Alessandra Lucini Paioni Shehrazade Jekhmane Joseph Lorent Alexandre M. J. J. Bonvin Marc Baldus Moreno Lelli Edwin J. A. Veldhuizen Eefjan Breukink Ishwar Singh Markus Weingarth Mode of action of teixobactins in cellular membranes
description	The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind to Lipid II in anionic cellular membranes.
format	article
author	Rhythm Shukla João Medeiros-Silva Anish Parmar Bram J. A. Vermeulen Sanjit Das Alessandra Lucini Paioni Shehrazade Jekhmane Joseph Lorent Alexandre M. J. J. Bonvin Marc Baldus Moreno Lelli Edwin J. A. Veldhuizen Eefjan Breukink Ishwar Singh Markus Weingarth
author_facet	Rhythm Shukla João Medeiros-Silva Anish Parmar Bram J. A. Vermeulen Sanjit Das Alessandra Lucini Paioni Shehrazade Jekhmane Joseph Lorent Alexandre M. J. J. Bonvin Marc Baldus Moreno Lelli Edwin J. A. Veldhuizen Eefjan Breukink Ishwar Singh Markus Weingarth
author_sort	Rhythm Shukla
title	Mode of action of teixobactins in cellular membranes
title_short	Mode of action of teixobactins in cellular membranes
title_full	Mode of action of teixobactins in cellular membranes
title_fullStr	Mode of action of teixobactins in cellular membranes
title_full_unstemmed	Mode of action of teixobactins in cellular membranes
title_sort	mode of action of teixobactins in cellular membranes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a53feac384048deba131cc874db54f3
work_keys_str_mv	AT rhythmshukla modeofactionofteixobactinsincellularmembranes AT joaomedeirossilva modeofactionofteixobactinsincellularmembranes AT anishparmar modeofactionofteixobactinsincellularmembranes AT bramjavermeulen modeofactionofteixobactinsincellularmembranes AT sanjitdas modeofactionofteixobactinsincellularmembranes AT alessandralucinipaioni modeofactionofteixobactinsincellularmembranes AT shehrazadejekhmane modeofactionofteixobactinsincellularmembranes AT josephlorent modeofactionofteixobactinsincellularmembranes AT alexandremjjbonvin modeofactionofteixobactinsincellularmembranes AT marcbaldus modeofactionofteixobactinsincellularmembranes AT morenolelli modeofactionofteixobactinsincellularmembranes AT edwinjaveldhuizen modeofactionofteixobactinsincellularmembranes AT eefjanbreukink modeofactionofteixobactinsincellularmembranes AT ishwarsingh modeofactionofteixobactinsincellularmembranes AT markusweingarth modeofactionofteixobactinsincellularmembranes
_version_	1718379296379109376

Mode of action of teixobactins in cellular membranes

Ejemplares similares