Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signaling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Wenyu Wang, Yen-An Tang, Qian Xiao, Wee Chyan Lee, Bing Cheng, Zhitong Niu, Gokce Oguz, Min Feng, Puay Leng Lee, Baojie Li, Zi-huan Yang, Yu-feng Chen, Ping Lan, Xiao-Jian Wu, Qiang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a553e70c8d44ce0a3bbc3c4e74a210a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a553e70c8d44ce0a3bbc3c4e74a210a
record_format	dspace
spelling	oai:doaj.org-article:8a553e70c8d44ce0a3bbc3c4e74a210a2021-12-02T16:26:32ZStromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer10.1038/s41467-021-24687-42041-1723https://doaj.org/article/8a553e70c8d44ce0a3bbc3c4e74a210a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24687-4https://doaj.org/toc/2041-1723BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signaling.Wenyu WangYen-An TangQian XiaoWee Chyan LeeBing ChengZhitong NiuGokce OguzMin FengPuay Leng LeeBaojie LiZi-huan YangYu-feng ChenPing LanXiao-Jian WuQiang YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenyu Wang Yen-An Tang Qian Xiao Wee Chyan Lee Bing Cheng Zhitong Niu Gokce Oguz Min Feng Puay Leng Lee Baojie Li Zi-huan Yang Yu-feng Chen Ping Lan Xiao-Jian Wu Qiang Yu Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
description	BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signaling.
format	article
author	Wenyu Wang Yen-An Tang Qian Xiao Wee Chyan Lee Bing Cheng Zhitong Niu Gokce Oguz Min Feng Puay Leng Lee Baojie Li Zi-huan Yang Yu-feng Chen Ping Lan Xiao-Jian Wu Qiang Yu
author_facet	Wenyu Wang Yen-An Tang Qian Xiao Wee Chyan Lee Bing Cheng Zhitong Niu Gokce Oguz Min Feng Puay Leng Lee Baojie Li Zi-huan Yang Yu-feng Chen Ping Lan Xiao-Jian Wu Qiang Yu
author_sort	Wenyu Wang
title	Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
title_short	Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
title_full	Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
title_fullStr	Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
title_full_unstemmed	Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
title_sort	stromal induction of brd4 phosphorylation results in chromatin remodeling and bet inhibitor resistance in colorectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a553e70c8d44ce0a3bbc3c4e74a210a
work_keys_str_mv	AT wenyuwang stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT yenantang stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT qianxiao stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT weechyanlee stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT bingcheng stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT zhitongniu stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT gokceoguz stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT minfeng stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT puaylenglee stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT baojieli stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT zihuanyang stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT yufengchen stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT pinglan stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT xiaojianwu stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer AT qiangyu stromalinductionofbrd4phosphorylationresultsinchromatinremodelingandbetinhibitorresistanceincolorectalcancer
_version_	1718384002508783616

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

Ejemplares similares