Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer

In the present study, nickel nanoparticles were green-synthesized using the aqueous extract of Fumaria officinalis. The synthesized NiNPs@F. officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The antioxidant and anti-ovarian cancer activity of NiN...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yan Huang, Chunxia Zhu, Rongkai Xie, Ming Ni
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	green synthesis chemical characterization nickel nanoparticles anti-ovarian cancer antioxidant Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/8a5c0cdcc74e4f138b100813b522fd30
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a5c0cdcc74e4f138b100813b522fd30
record_format	dspace
spelling	oai:doaj.org-article:8a5c0cdcc74e4f138b100813b522fd302021-11-04T15:00:42ZGreen synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer1745-80801745-809910.1080/17458080.2021.1975037https://doaj.org/article/8a5c0cdcc74e4f138b100813b522fd302021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/17458080.2021.1975037https://doaj.org/toc/1745-8080https://doaj.org/toc/1745-8099In the present study, nickel nanoparticles were green-synthesized using the aqueous extract of Fumaria officinalis. The synthesized NiNPs@F. officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The antioxidant and anti-ovarian cancer activity of NiNPs@F. officinalis was evaluated. The nanoparticles were formed in a spherical shape in the range of 16.85 to 49.04 nm for the particle size. In the antioxidant test, the IC50 of F. officinalis, NiNPs@F. officinalis, and BHT against DPPH free radicals were 253, 145, and 107 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with NiNPs@F. officinalis were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. PA-1, Caov-3, SW-626, and SK-OV-3. The viability of malignant ovarian cell line reduced dose-dependently in the presence of NiNPs@F. officinalis. The IC50 of NiNPs@F. officinalis were 375, 225, 246, and 279 µg/mL against PA-1, Caov-3, SW-626, and SK-OV-3 cell lines, respectively. After the clinical study, nickel nanoparticles containing F. officinalis leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human ovarian cancer.Yan HuangChunxia ZhuRongkai XieMing NiTaylor & Francis Grouparticlegreen synthesischemical characterizationnickel nanoparticlesanti-ovarian cancerantioxidantMaterials of engineering and construction. Mechanics of materialsTA401-492Chemical technologyTP1-1185ENJournal of Experimental Nanoscience, Vol 16, Iss 1, Pp 369-382 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	green synthesis chemical characterization nickel nanoparticles anti-ovarian cancer antioxidant Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185
spellingShingle	green synthesis chemical characterization nickel nanoparticles anti-ovarian cancer antioxidant Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185 Yan Huang Chunxia Zhu Rongkai Xie Ming Ni Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
description	In the present study, nickel nanoparticles were green-synthesized using the aqueous extract of Fumaria officinalis. The synthesized NiNPs@F. officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The antioxidant and anti-ovarian cancer activity of NiNPs@F. officinalis was evaluated. The nanoparticles were formed in a spherical shape in the range of 16.85 to 49.04 nm for the particle size. In the antioxidant test, the IC50 of F. officinalis, NiNPs@F. officinalis, and BHT against DPPH free radicals were 253, 145, and 107 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with NiNPs@F. officinalis were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. PA-1, Caov-3, SW-626, and SK-OV-3. The viability of malignant ovarian cell line reduced dose-dependently in the presence of NiNPs@F. officinalis. The IC50 of NiNPs@F. officinalis were 375, 225, 246, and 279 µg/mL against PA-1, Caov-3, SW-626, and SK-OV-3 cell lines, respectively. After the clinical study, nickel nanoparticles containing F. officinalis leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human ovarian cancer.
format	article
author	Yan Huang Chunxia Zhu Rongkai Xie Ming Ni
author_facet	Yan Huang Chunxia Zhu Rongkai Xie Ming Ni
author_sort	Yan Huang
title	Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
title_short	Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
title_full	Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
title_fullStr	Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
title_full_unstemmed	Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
title_sort	green synthesis of nickel nanoparticles using fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/8a5c0cdcc74e4f138b100813b522fd30
work_keys_str_mv	AT yanhuang greensynthesisofnickelnanoparticlesusingfumariaofficinalisasanovelchemotherapeuticdrugforthetreatmentofovariancancer AT chunxiazhu greensynthesisofnickelnanoparticlesusingfumariaofficinalisasanovelchemotherapeuticdrugforthetreatmentofovariancancer AT rongkaixie greensynthesisofnickelnanoparticlesusingfumariaofficinalisasanovelchemotherapeuticdrugforthetreatmentofovariancancer AT mingni greensynthesisofnickelnanoparticlesusingfumariaofficinalisasanovelchemotherapeuticdrugforthetreatmentofovariancancer
_version_	1718444784148807680

Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer

Ejemplares similares