Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

Studies described so far suggest that human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal role in enhancing immunity was proved in infa...

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Autores principales:	Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human β-defensin hBD-2 small antimicrobial peptides innate immunity epithelium Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8a607c6a74464f3488a125646f7de070
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spelling	oai:doaj.org-article:8a607c6a74464f3488a125646f7de0702021-11-25T17:10:09ZHuman β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response10.3390/cells101129912073-4409https://doaj.org/article/8a607c6a74464f3488a125646f7de0702021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2991https://doaj.org/toc/2073-4409Studies described so far suggest that human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal role in enhancing immunity was proved in infants. It may also be considered a marker of inflammation. Its therapeutic administration has been suggested for maintenance of the balance of systemic homeostasis based on the appropriate composition of the microbiota. It has been suggested that it may be an important therapeutic tool for modulating the response of the immune system in many inflammatory diseases, offering new treatment modalities. For this reason, its properties and role in the human body discussed in this review should be studied in more detail.Martyna CieślikNatalia BagińskaAndrzej GórskiEwa Jończyk-MatysiakMDPI AGarticlehuman β-defensinhBD-2small antimicrobial peptidesinnate immunityepitheliumBiology (General)QH301-705.5ENCells, Vol 10, Iss 2991, p 2991 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human β-defensin hBD-2 small antimicrobial peptides innate immunity epithelium Biology (General) QH301-705.5
spellingShingle	human β-defensin hBD-2 small antimicrobial peptides innate immunity epithelium Biology (General) QH301-705.5 Martyna Cieślik Natalia Bagińska Andrzej Górski Ewa Jończyk-Matysiak Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
description	Studies described so far suggest that human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal role in enhancing immunity was proved in infants. It may also be considered a marker of inflammation. Its therapeutic administration has been suggested for maintenance of the balance of systemic homeostasis based on the appropriate composition of the microbiota. It has been suggested that it may be an important therapeutic tool for modulating the response of the immune system in many inflammatory diseases, offering new treatment modalities. For this reason, its properties and role in the human body discussed in this review should be studied in more detail.
format	article
author	Martyna Cieślik Natalia Bagińska Andrzej Górski Ewa Jończyk-Matysiak
author_facet	Martyna Cieślik Natalia Bagińska Andrzej Górski Ewa Jończyk-Matysiak
author_sort	Martyna Cieślik
title	Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
title_short	Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
title_full	Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
title_fullStr	Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
title_full_unstemmed	Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response
title_sort	human β-defensin 2 and its postulated role in modulation of the immune response
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8a607c6a74464f3488a125646f7de070
work_keys_str_mv	AT martynacieslik humanbdefensin2anditspostulatedroleinmodulationoftheimmuneresponse AT nataliabaginska humanbdefensin2anditspostulatedroleinmodulationoftheimmuneresponse AT andrzejgorski humanbdefensin2anditspostulatedroleinmodulationoftheimmuneresponse AT ewajonczykmatysiak humanbdefensin2anditspostulatedroleinmodulationoftheimmuneresponse
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Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

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