Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

Hepatocellular carcinoma is known to harbour numerous genomic and epigenomic aberrations, driving transcriptomic deregulation. Here, the authors integrate genomic, epigenomic, and expression data to reveal three prognostic subtypes, providing insight to the pathobiology of hepatocellular carcinoma.

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Autores principales: Hyun Goo Woo, Ji-Hye Choi, Sarah Yoon, Byul A. Jee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Yoon Jun Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8a60c24eeaad425dbc3d1059ee545d95
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spelling oai:doaj.org-article:8a60c24eeaad425dbc3d1059ee545d952021-12-02T15:38:44ZIntegrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer10.1038/s41467-017-00991-w2041-1723https://doaj.org/article/8a60c24eeaad425dbc3d1059ee545d952017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00991-whttps://doaj.org/toc/2041-1723Hepatocellular carcinoma is known to harbour numerous genomic and epigenomic aberrations, driving transcriptomic deregulation. Here, the authors integrate genomic, epigenomic, and expression data to reveal three prognostic subtypes, providing insight to the pathobiology of hepatocellular carcinoma.Hyun Goo WooJi-Hye ChoiSarah YoonByul A. JeeEun Ju ChoJeong-Hoon LeeSu Jong YuJung-Hwan YoonNam-Joon YiKwang-Woong LeeKyung-Suk SuhYoon Jun KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyun Goo Woo
Ji-Hye Choi
Sarah Yoon
Byul A. Jee
Eun Ju Cho
Jeong-Hoon Lee
Su Jong Yu
Jung-Hwan Yoon
Nam-Joon Yi
Kwang-Woong Lee
Kyung-Suk Suh
Yoon Jun Kim
Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
description Hepatocellular carcinoma is known to harbour numerous genomic and epigenomic aberrations, driving transcriptomic deregulation. Here, the authors integrate genomic, epigenomic, and expression data to reveal three prognostic subtypes, providing insight to the pathobiology of hepatocellular carcinoma.
format article
author Hyun Goo Woo
Ji-Hye Choi
Sarah Yoon
Byul A. Jee
Eun Ju Cho
Jeong-Hoon Lee
Su Jong Yu
Jung-Hwan Yoon
Nam-Joon Yi
Kwang-Woong Lee
Kyung-Suk Suh
Yoon Jun Kim
author_facet Hyun Goo Woo
Ji-Hye Choi
Sarah Yoon
Byul A. Jee
Eun Ju Cho
Jeong-Hoon Lee
Su Jong Yu
Jung-Hwan Yoon
Nam-Joon Yi
Kwang-Woong Lee
Kyung-Suk Suh
Yoon Jun Kim
author_sort Hyun Goo Woo
title Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
title_short Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
title_full Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
title_fullStr Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
title_full_unstemmed Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
title_sort integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8a60c24eeaad425dbc3d1059ee545d95
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AT sarahyoon integrativeanalysisofgenomicandepigenomicregulationofthetranscriptomeinlivercancer
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