Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation

Background Younger age at final menstrual period (FMP) is associated with increased risk for cardiovascular disease events. This paper evaluated whether older age at FMP is associated with more favorable patterns of lipid changes during the menopause transition and whether these changes are associat...

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Autores principales:	Karen A. Matthews, Xirun Chen, Emma Barinas‐Mitchell, Maria M. Brooks, Carol A. Derby, Sioban Harlow, Elizabeth A. Jackson, Rebecca C. Thurston, Samar R. El Khoudary
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	aging carotid disease lipids menopause longitudinal cohort study Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/8a62c1e5e3bf4d03bd9267684ee67e49
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spelling	oai:doaj.org-article:8a62c1e5e3bf4d03bd9267684ee67e492021-11-23T11:36:35ZAge at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation10.1161/JAHA.121.0213622047-9980https://doaj.org/article/8a62c1e5e3bf4d03bd9267684ee67e492021-09-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.021362https://doaj.org/toc/2047-9980Background Younger age at final menstrual period (FMP) is associated with increased risk for cardiovascular disease events. This paper evaluated whether older age at FMP is associated with more favorable patterns of lipid changes during the menopause transition and whether these changes are associated with less subclinical carotid disease in the postmenopausal years. Methods and Results Lipids and lipoproteins were measured repeatedly among 1554 premenopausal women who had a natural menopause during follow‐up years (median=18.8 years); a subset of 890 women also had measures of carotid intima media thickness, adventitial diameter, and plaque. Women who had an older FMP age had less adverse changes in cholesterol from 1 to 3 years after FMP, and in triglycerides from FMP to 3 years after FMP, but they had more adverse changes in ApoB and Apo A1 from 3 years before to 1 year after the FMP. Increasing cholesterol and ApoB from 1 to 3 years after FMP were associated with greater intima media thickness and adventitial diameter, and the greater likelihood of a plaque score >2 the older the age at FMP. Conclusions Despite the epidemiological literature showing early age at FMP is associated with elevated risk for cardiovascular disease events, older age at FMP had inconsistent associations with less adverse lipid changes in midlife, which did not translate into less risk for subclinical carotid disease and in some cases more risk. These findings are restricted to women who experience FMP in the normative age range for the menopausal transition.Karen A. MatthewsXirun ChenEmma Barinas‐MitchellMaria M. BrooksCarol A. DerbySioban HarlowElizabeth A. JacksonRebecca C. ThurstonSamar R. El KhoudaryWileyarticleagingcarotid diseaselipidsmenopauselongitudinal cohort studyDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging carotid disease lipids menopause longitudinal cohort study Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	aging carotid disease lipids menopause longitudinal cohort study Diseases of the circulatory (Cardiovascular) system RC666-701 Karen A. Matthews Xirun Chen Emma Barinas‐Mitchell Maria M. Brooks Carol A. Derby Sioban Harlow Elizabeth A. Jackson Rebecca C. Thurston Samar R. El Khoudary Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation
description	Background Younger age at final menstrual period (FMP) is associated with increased risk for cardiovascular disease events. This paper evaluated whether older age at FMP is associated with more favorable patterns of lipid changes during the menopause transition and whether these changes are associated with less subclinical carotid disease in the postmenopausal years. Methods and Results Lipids and lipoproteins were measured repeatedly among 1554 premenopausal women who had a natural menopause during follow‐up years (median=18.8 years); a subset of 890 women also had measures of carotid intima media thickness, adventitial diameter, and plaque. Women who had an older FMP age had less adverse changes in cholesterol from 1 to 3 years after FMP, and in triglycerides from FMP to 3 years after FMP, but they had more adverse changes in ApoB and Apo A1 from 3 years before to 1 year after the FMP. Increasing cholesterol and ApoB from 1 to 3 years after FMP were associated with greater intima media thickness and adventitial diameter, and the greater likelihood of a plaque score >2 the older the age at FMP. Conclusions Despite the epidemiological literature showing early age at FMP is associated with elevated risk for cardiovascular disease events, older age at FMP had inconsistent associations with less adverse lipid changes in midlife, which did not translate into less risk for subclinical carotid disease and in some cases more risk. These findings are restricted to women who experience FMP in the normative age range for the menopausal transition.
format	article
author	Karen A. Matthews Xirun Chen Emma Barinas‐Mitchell Maria M. Brooks Carol A. Derby Sioban Harlow Elizabeth A. Jackson Rebecca C. Thurston Samar R. El Khoudary
author_facet	Karen A. Matthews Xirun Chen Emma Barinas‐Mitchell Maria M. Brooks Carol A. Derby Sioban Harlow Elizabeth A. Jackson Rebecca C. Thurston Samar R. El Khoudary
author_sort	Karen A. Matthews
title	Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation
title_short	Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation
title_full	Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation
title_fullStr	Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation
title_full_unstemmed	Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation
title_sort	age at menopause in relationship to lipid changes and subclinical carotid disease across 20 years: study of women's health across the nation
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/8a62c1e5e3bf4d03bd9267684ee67e49
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Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation

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