Defective chromatin architectures in embryonic stem cells derived from somatic cell nuclear transfer impair their differentiation potentials

Defective chromatin architectures in embryonic stem cells derived from somatic cell nuclear transfer impair their differentiation potentials

Abstract Nuclear transfer embryonic stem cells (ntESCs) hold enormous promise for individual-specific regenerative medicine. However, the chromatin states of ntESCs remain poorly characterized. In this study, we employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and three-d...

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Autores principales: Dan-Ya Wu, Xinxin Li, Qiao-Ran Sun, Cheng-Li Dou, Tian Xu, Hainan He, Han Luo, Haitao Fu, Guo-Wei Bu, Bingbing Luo, Xia Zhang, Bin-Guang Ma, Cheng Peng, Yi-Liang Miao
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/8a636afc1a2b4f8fb72815c6b5276ed8
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