Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis

Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.

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Autores principales:	Joshua M. Boucher, Ryan P. Clark, Diana C. Chong, Kathryn M. Citrin, Lyndsay A. Wylie, Victoria L. Bautch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a6449f75bca4d14bde1f8777d50adc4
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spelling	oai:doaj.org-article:8a6449f75bca4d14bde1f8777d50adc42021-12-02T14:41:18ZDynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis10.1038/ncomms156992041-1723https://doaj.org/article/8a6449f75bca4d14bde1f8777d50adc42017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15699https://doaj.org/toc/2041-1723Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.Joshua M. BoucherRyan P. ClarkDiana C. ChongKathryn M. CitrinLyndsay A. WylieVictoria L. BautchNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
description	Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.
format	article
author	Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch
author_facet	Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch
author_sort	Joshua M. Boucher
title	Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
title_short	Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
title_full	Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
title_fullStr	Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
title_full_unstemmed	Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
title_sort	dynamic alterations in decoy vegf receptor-1 stability regulate angiogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a6449f75bca4d14bde1f8777d50adc4
work_keys_str_mv	AT joshuamboucher dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT ryanpclark dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT dianacchong dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT kathrynmcitrin dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT lyndsayawylie dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT victorialbautch dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis
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Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis

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