Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis

Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis

Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.

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Autores principales: Joshua M. Boucher, Ryan P. Clark, Diana C. Chong, Kathryn M. Citrin, Lyndsay A. Wylie, Victoria L. Bautch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/8a6449f75bca4d14bde1f8777d50adc4
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