LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding

Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chun-Shik Shin, Shuxia Meng, Spiros D. Garbis, Annie Moradian, Robert W. Taylor, Michael J. Sweredoski, Brett Lomenick, David C. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a65c368ecc04a4481d331a0a80d8431
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a65c368ecc04a4481d331a0a80d8431
record_format	dspace
spelling	oai:doaj.org-article:8a65c368ecc04a4481d331a0a80d84312021-12-02T14:11:57ZLONP1 and mtHSP70 cooperate to promote mitochondrial protein folding10.1038/s41467-020-20597-z2041-1723https://doaj.org/article/8a65c368ecc04a4481d331a0a80d84312021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20597-zhttps://doaj.org/toc/2041-1723Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.Chun-Shik ShinShuxia MengSpiros D. GarbisAnnie MoradianRobert W. TaylorMichael J. SweredoskiBrett LomenickDavid C. ChanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Shik Shin Shuxia Meng Spiros D. Garbis Annie Moradian Robert W. Taylor Michael J. Sweredoski Brett Lomenick David C. Chan LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
description	Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.
format	article
author	Chun-Shik Shin Shuxia Meng Spiros D. Garbis Annie Moradian Robert W. Taylor Michael J. Sweredoski Brett Lomenick David C. Chan
author_facet	Chun-Shik Shin Shuxia Meng Spiros D. Garbis Annie Moradian Robert W. Taylor Michael J. Sweredoski Brett Lomenick David C. Chan
author_sort	Chun-Shik Shin
title	LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
title_short	LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
title_full	LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
title_fullStr	LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
title_full_unstemmed	LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
title_sort	lonp1 and mthsp70 cooperate to promote mitochondrial protein folding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a65c368ecc04a4481d331a0a80d8431
work_keys_str_mv	AT chunshikshin lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT shuxiameng lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT spirosdgarbis lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT anniemoradian lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT robertwtaylor lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT michaeljsweredoski lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT brettlomenick lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding AT davidcchan lonp1andmthsp70cooperatetopromotemitochondrialproteinfolding
_version_	1718391856187834368

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding

Ejemplares similares