Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process

Math heals: Using computational methods to improve design of wound healing assay Cell motility is a central process in wound healing and relies on complex cell-cell interactions. A team of mathematicians led by Ruth Baker and Kit Yates at the University of Oxford utilised computer simulations to re-...

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Autores principales:	Robert J. H. Ross, R. E. Baker, Andrew Parker, M. J. Ford, R. L. Mort, C. A. Yates
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8a660ffbc4ef4cdea764d20b19e6fd5d
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spelling	oai:doaj.org-article:8a660ffbc4ef4cdea764d20b19e6fd5d2021-12-02T15:10:32ZUsing approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process10.1038/s41540-017-0010-72056-7189https://doaj.org/article/8a660ffbc4ef4cdea764d20b19e6fd5d2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0010-7https://doaj.org/toc/2056-7189Math heals: Using computational methods to improve design of wound healing assay Cell motility is a central process in wound healing and relies on complex cell-cell interactions. A team of mathematicians led by Ruth Baker and Kit Yates at the University of Oxford utilised computer simulations to re-design wound-healing assays that efficiently identify cell motility parameters. New experimental designs through computer simulation can more accurately identify cell motility parameters by expanding the size of the domain upon which the experiment is performed, as opposed to increasing the number of experimental replicates. The results describe time and cost-saving alterations for an experimental method for evaluate complex cell-cell interactions.Robert J. H. RossR. E. BakerAndrew ParkerM. J. FordR. L. MortC. A. YatesNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Robert J. H. Ross R. E. Baker Andrew Parker M. J. Ford R. L. Mort C. A. Yates Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
description	Math heals: Using computational methods to improve design of wound healing assay Cell motility is a central process in wound healing and relies on complex cell-cell interactions. A team of mathematicians led by Ruth Baker and Kit Yates at the University of Oxford utilised computer simulations to re-design wound-healing assays that efficiently identify cell motility parameters. New experimental designs through computer simulation can more accurately identify cell motility parameters by expanding the size of the domain upon which the experiment is performed, as opposed to increasing the number of experimental replicates. The results describe time and cost-saving alterations for an experimental method for evaluate complex cell-cell interactions.
format	article
author	Robert J. H. Ross R. E. Baker Andrew Parker M. J. Ford R. L. Mort C. A. Yates
author_facet	Robert J. H. Ross R. E. Baker Andrew Parker M. J. Ford R. L. Mort C. A. Yates
author_sort	Robert J. H. Ross
title	Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_short	Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_full	Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_fullStr	Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_full_unstemmed	Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
title_sort	using approximate bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a660ffbc4ef4cdea764d20b19e6fd5d
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Using approximate Bayesian computation to quantify cell–cell adhesion parameters in a cell migratory process

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