Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall

Abstract Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections because of their poor bioavailability vi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fraser Stewart, Gerard Cummins, Mihnea V. Turcanu, Benjamin F. Cox, Alan Prescott, Eddie Clutton, Ian P. Newton, Marc P. Y. Desmulliez, Maya Thanou, Helen Mulvana, Sandy Cochran, Inke Näthke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a687ae1f41f4e86a9b87525b6ae78db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a687ae1f41f4e86a9b87525b6ae78db
record_format	dspace
spelling	oai:doaj.org-article:8a687ae1f41f4e86a9b87525b6ae78db2021-12-02T14:16:26ZUltrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall10.1038/s41598-021-82240-12045-2322https://doaj.org/article/8a687ae1f41f4e86a9b87525b6ae78db2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82240-1https://doaj.org/toc/2045-2322Abstract Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections because of their poor bioavailability via oral routes. Delivery of biologics to the small intestine using electronic delivery with devices that are similar to capsule endoscopes is a promising means of overcoming this limitation and does not require reformulation of the therapeutic agent. The efficacy of such capsule devices for drug delivery could be further improved by increasing the permeability of the intestinal tract lining with an integrated ultrasound transducer to increase uptake. This paper describes a novel proof of concept capsule device capable of electronic application of focused ultrasound and delivery of therapeutic agents. Fluorescent markers, which were chosen as a model drug, were used to demonstrate in vivo delivery in the porcine small intestine with this capsule. We show that the fluorescent markers can penetrate the mucus layer of the small intestine at low acoustic powers when combining microbubbles with focused ultrasound during in vivo experiments using porcine models. This study illustrates how such a device could be potentially used for gastrointestinal drug delivery and the challenges to be overcome before focused ultrasound and microbubbles could be used with this device for the oral delivery of biologic therapeutics.Fraser StewartGerard CumminsMihnea V. TurcanuBenjamin F. CoxAlan PrescottEddie CluttonIan P. NewtonMarc P. Y. DesmulliezMaya ThanouHelen MulvanaSandy CochranInke NäthkeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fraser Stewart Gerard Cummins Mihnea V. Turcanu Benjamin F. Cox Alan Prescott Eddie Clutton Ian P. Newton Marc P. Y. Desmulliez Maya Thanou Helen Mulvana Sandy Cochran Inke Näthke Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
description	Abstract Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections because of their poor bioavailability via oral routes. Delivery of biologics to the small intestine using electronic delivery with devices that are similar to capsule endoscopes is a promising means of overcoming this limitation and does not require reformulation of the therapeutic agent. The efficacy of such capsule devices for drug delivery could be further improved by increasing the permeability of the intestinal tract lining with an integrated ultrasound transducer to increase uptake. This paper describes a novel proof of concept capsule device capable of electronic application of focused ultrasound and delivery of therapeutic agents. Fluorescent markers, which were chosen as a model drug, were used to demonstrate in vivo delivery in the porcine small intestine with this capsule. We show that the fluorescent markers can penetrate the mucus layer of the small intestine at low acoustic powers when combining microbubbles with focused ultrasound during in vivo experiments using porcine models. This study illustrates how such a device could be potentially used for gastrointestinal drug delivery and the challenges to be overcome before focused ultrasound and microbubbles could be used with this device for the oral delivery of biologic therapeutics.
format	article
author	Fraser Stewart Gerard Cummins Mihnea V. Turcanu Benjamin F. Cox Alan Prescott Eddie Clutton Ian P. Newton Marc P. Y. Desmulliez Maya Thanou Helen Mulvana Sandy Cochran Inke Näthke
author_facet	Fraser Stewart Gerard Cummins Mihnea V. Turcanu Benjamin F. Cox Alan Prescott Eddie Clutton Ian P. Newton Marc P. Y. Desmulliez Maya Thanou Helen Mulvana Sandy Cochran Inke Näthke
author_sort	Fraser Stewart
title	Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
title_short	Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
title_full	Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
title_fullStr	Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
title_full_unstemmed	Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
title_sort	ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a687ae1f41f4e86a9b87525b6ae78db
work_keys_str_mv	AT fraserstewart ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT gerardcummins ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT mihneavturcanu ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT benjaminfcox ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT alanprescott ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT eddieclutton ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT ianpnewton ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT marcpydesmulliez ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT mayathanou ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT helenmulvana ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT sandycochran ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall AT inkenathke ultrasoundmediateddeliveryofquantumdotsfromaproofofconceptcapsuleendoscopetothegastrointestinalwall
_version_	1718391679932694528

Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall

Ejemplares similares