Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma

Abstract To identify risk factors for infection in patients with diffuse large B cell lymphoma (DLBCL) undergoing rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone (R-CHOP) treatment. All patients with DLBCL who received R-CHOP from 2004–2014 in a tertiary Australian hospital wer...

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Autores principales:	Claire Dendle, Michael Gilbertson, Tim Spelman, Rhonda L. Stuart, Tony M. Korman, Karin Thursky, Stephen Opat, Zoe McQuilten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a6a1943b81149ab8bde5882ee1cadd6
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spelling	oai:doaj.org-article:8a6a1943b81149ab8bde5882ee1cadd62021-12-02T16:06:07ZInfection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma10.1038/s41598-017-04495-x2045-2322https://doaj.org/article/8a6a1943b81149ab8bde5882ee1cadd62017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04495-xhttps://doaj.org/toc/2045-2322Abstract To identify risk factors for infection in patients with diffuse large B cell lymphoma (DLBCL) undergoing rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone (R-CHOP) treatment. All patients with DLBCL who received R-CHOP from 2004–2014 in a tertiary Australian hospital were identified and information collected from hospital admission data, laboratory results and medical record review. Infection was defined as hospitalisation with an ICD-10-AM diagnostic code for infection. Risk factors for infection and association between infection and survival were modelled using Cox proportional hazards regression. Over the 10-year period there were 325 patients; 191 (58.8%) males, median age 66 years. 206 (63.4%) patients experienced ≥1 infection. Independent predictors of infection were Charlson comorbidity index score (hazard ratio [HR] 3.60, p = 0.002), Eastern Cooperative Oncology Group (ECOG) performance status (HR 2.09 p = <0.001) and neutropenia (HR 2.46, p = <0.001). 99 (31%) patients died. Infection was an independent predictor of survival (HR 3.27, p = <0.001, as were age (HR 2.49, p = 0.001), Charlson comorbidity index (HR 4.34, p = <0.001), ECOG performance status (HR 4.33, p = 0.045) and neutropenia (HR 1.95, p = 0.047). Infections are common and infection itself is an independent predictor of survival. Patients at highest risk of infection and death are those with multiple comorbidities, poor performance status and neutropenia.Claire DendleMichael GilbertsonTim SpelmanRhonda L. StuartTony M. KormanKarin ThurskyStephen OpatZoe McQuiltenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Dendle Michael Gilbertson Tim Spelman Rhonda L. Stuart Tony M. Korman Karin Thursky Stephen Opat Zoe McQuilten Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
description	Abstract To identify risk factors for infection in patients with diffuse large B cell lymphoma (DLBCL) undergoing rituximab, cyclophosphamide, vincristine, adriamycin and prednisolone (R-CHOP) treatment. All patients with DLBCL who received R-CHOP from 2004–2014 in a tertiary Australian hospital were identified and information collected from hospital admission data, laboratory results and medical record review. Infection was defined as hospitalisation with an ICD-10-AM diagnostic code for infection. Risk factors for infection and association between infection and survival were modelled using Cox proportional hazards regression. Over the 10-year period there were 325 patients; 191 (58.8%) males, median age 66 years. 206 (63.4%) patients experienced ≥1 infection. Independent predictors of infection were Charlson comorbidity index score (hazard ratio [HR] 3.60, p = 0.002), Eastern Cooperative Oncology Group (ECOG) performance status (HR 2.09 p = <0.001) and neutropenia (HR 2.46, p = <0.001). 99 (31%) patients died. Infection was an independent predictor of survival (HR 3.27, p = <0.001, as were age (HR 2.49, p = 0.001), Charlson comorbidity index (HR 4.34, p = <0.001), ECOG performance status (HR 4.33, p = 0.045) and neutropenia (HR 1.95, p = 0.047). Infections are common and infection itself is an independent predictor of survival. Patients at highest risk of infection and death are those with multiple comorbidities, poor performance status and neutropenia.
format	article
author	Claire Dendle Michael Gilbertson Tim Spelman Rhonda L. Stuart Tony M. Korman Karin Thursky Stephen Opat Zoe McQuilten
author_facet	Claire Dendle Michael Gilbertson Tim Spelman Rhonda L. Stuart Tony M. Korman Karin Thursky Stephen Opat Zoe McQuilten
author_sort	Claire Dendle
title	Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
title_short	Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
title_full	Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
title_fullStr	Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
title_full_unstemmed	Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma
title_sort	infection is an independent predictor of death in diffuse large b cell lymphoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a6a1943b81149ab8bde5882ee1cadd6
work_keys_str_mv	AT clairedendle infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT michaelgilbertson infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT timspelman infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT rhondalstuart infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT tonymkorman infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT karinthursky infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT stephenopat infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma AT zoemcquilten infectionisanindependentpredictorofdeathindiffuselargebcelllymphoma
_version_	1718385100115148800

Infection is an Independent Predictor of Death in Diffuse Large B Cell Lymphoma

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