Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

Abstract Background HIV and HBV infections remain responsible for high rate of morbidity and mortality in many African Countries, affecting women and newborns. This study aims to analyze the spatial pattern of HIV and HBV infections in pregnant women in Luanda, Angola, and the statistical associatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amélia Nkutxi Vueba, Ricardo Almendra, Paula Santana, Clarissa Faria, Maria do Céu Sousa
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Virus Sexually transmission infections Seroprevalence HIV Antibodies HBsAg Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8a6b54248f624e6eb4e2e22ae36fa1ea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a6b54248f624e6eb4e2e22ae36fa1ea
record_format	dspace
spelling	oai:doaj.org-article:8a6b54248f624e6eb4e2e22ae36fa1ea2021-12-05T12:03:07ZPrevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants10.1186/s12985-021-01698-71743-422Xhttps://doaj.org/article/8a6b54248f624e6eb4e2e22ae36fa1ea2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01698-7https://doaj.org/toc/1743-422XAbstract Background HIV and HBV infections remain responsible for high rate of morbidity and mortality in many African Countries, affecting women and newborns. This study aims to analyze the spatial pattern of HIV and HBV infections in pregnant women in Luanda, Angola, and the statistical association between HIV and HBV and socio-economic characteristics, hygiene, and health status. Methods Detection of anti-HIV antibodies (total anti-HIV-1, anti-HIV-2 and HIV-1 p24 antigen) and Hepatitis B antigens (HBsAg, HBeAg) and antibodies (anti-HBc Total II, HBc IgM, Anti-HBsT II) was performed by Enzyme Linked Fluorescent Assay (ELFA) in serum samples of 878 pregnant women attended at the Lucrecia Paim Maternity Hospital (LPMH). Data were collected by questionnaire after written consent, and spatial distribution was assessed through a Kernel Density Function. The potential risk factors associated with HIV HBV infection were evaluated using bivariate and multivariate binomial logistic regression analysis. Results Anti-HIV antibodies were positive in 118 samples (13.4%) and HBV infection were positive in 226 (25.7%). The seroprevalence of HIV/HBV coinfection was of 6.3%. The results showed that the seroprevalence of HBV was similar in most municipalities: 25.8% in Belas; 26.6% in Viana; 27.6% in Luanda; 19.2% in Cacuaco; and 15.6% Cazenga. For HIV, the seroprevalence was also close ranges among the municipalities: 10.0% in Belas; 14.5% in Viana 14.9% in Luanda and 12.5% in Cazenga. However, the seroprevalence in municipality of in Cacuaco was lower (5.8%) and bivariate and multivariate analysis showed a lower risk for HIV in this area (OR 0.348, CI 0.083–0.986; OR 0.359, CI 0.085–1.021). The multivariate analysis had also showed a significant increased risk for HIV in women with 2 or 3 births (OR 1.860, CI 1.054–3.372). Conclusions Our results underlined the need to improve the screening and clinical follow-up of HIV and HBV in Angola, as well the educational campaigns to prevent not only the morbidity and mortality associated with these diseases, but also their transmission, mainly in women in reproductive age and pregnant, encouraging the pre-natal consultations in order to avoid mother-to-child transmission.Amélia Nkutxi VuebaRicardo AlmendraPaula SantanaClarissa FariaMaria do Céu SousaBMCarticleVirusSexually transmission infectionsSeroprevalenceHIVAntibodiesHBsAgInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Virus Sexually transmission infections Seroprevalence HIV Antibodies HBsAg Infectious and parasitic diseases RC109-216
spellingShingle	Virus Sexually transmission infections Seroprevalence HIV Antibodies HBsAg Infectious and parasitic diseases RC109-216 Amélia Nkutxi Vueba Ricardo Almendra Paula Santana Clarissa Faria Maria do Céu Sousa Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
description	Abstract Background HIV and HBV infections remain responsible for high rate of morbidity and mortality in many African Countries, affecting women and newborns. This study aims to analyze the spatial pattern of HIV and HBV infections in pregnant women in Luanda, Angola, and the statistical association between HIV and HBV and socio-economic characteristics, hygiene, and health status. Methods Detection of anti-HIV antibodies (total anti-HIV-1, anti-HIV-2 and HIV-1 p24 antigen) and Hepatitis B antigens (HBsAg, HBeAg) and antibodies (anti-HBc Total II, HBc IgM, Anti-HBsT II) was performed by Enzyme Linked Fluorescent Assay (ELFA) in serum samples of 878 pregnant women attended at the Lucrecia Paim Maternity Hospital (LPMH). Data were collected by questionnaire after written consent, and spatial distribution was assessed through a Kernel Density Function. The potential risk factors associated with HIV HBV infection were evaluated using bivariate and multivariate binomial logistic regression analysis. Results Anti-HIV antibodies were positive in 118 samples (13.4%) and HBV infection were positive in 226 (25.7%). The seroprevalence of HIV/HBV coinfection was of 6.3%. The results showed that the seroprevalence of HBV was similar in most municipalities: 25.8% in Belas; 26.6% in Viana; 27.6% in Luanda; 19.2% in Cacuaco; and 15.6% Cazenga. For HIV, the seroprevalence was also close ranges among the municipalities: 10.0% in Belas; 14.5% in Viana 14.9% in Luanda and 12.5% in Cazenga. However, the seroprevalence in municipality of in Cacuaco was lower (5.8%) and bivariate and multivariate analysis showed a lower risk for HIV in this area (OR 0.348, CI 0.083–0.986; OR 0.359, CI 0.085–1.021). The multivariate analysis had also showed a significant increased risk for HIV in women with 2 or 3 births (OR 1.860, CI 1.054–3.372). Conclusions Our results underlined the need to improve the screening and clinical follow-up of HIV and HBV in Angola, as well the educational campaigns to prevent not only the morbidity and mortality associated with these diseases, but also their transmission, mainly in women in reproductive age and pregnant, encouraging the pre-natal consultations in order to avoid mother-to-child transmission.
format	article
author	Amélia Nkutxi Vueba Ricardo Almendra Paula Santana Clarissa Faria Maria do Céu Sousa
author_facet	Amélia Nkutxi Vueba Ricardo Almendra Paula Santana Clarissa Faria Maria do Céu Sousa
author_sort	Amélia Nkutxi Vueba
title	Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
title_short	Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
title_full	Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
title_fullStr	Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
title_full_unstemmed	Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
title_sort	prevalence of hiv and hepatitis b virus among pregnant women in luanda (angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8a6b54248f624e6eb4e2e22ae36fa1ea
work_keys_str_mv	AT ameliankutxivueba prevalenceofhivandhepatitisbvirusamongpregnantwomeninluandaangolageospatialdistributionanditsassociationwithsociodemographicandclinicalobstetricdeterminants AT ricardoalmendra prevalenceofhivandhepatitisbvirusamongpregnantwomeninluandaangolageospatialdistributionanditsassociationwithsociodemographicandclinicalobstetricdeterminants AT paulasantana prevalenceofhivandhepatitisbvirusamongpregnantwomeninluandaangolageospatialdistributionanditsassociationwithsociodemographicandclinicalobstetricdeterminants AT clarissafaria prevalenceofhivandhepatitisbvirusamongpregnantwomeninluandaangolageospatialdistributionanditsassociationwithsociodemographicandclinicalobstetricdeterminants AT mariadoceusousa prevalenceofhivandhepatitisbvirusamongpregnantwomeninluandaangolageospatialdistributionanditsassociationwithsociodemographicandclinicalobstetricdeterminants
_version_	1718372329660088320

Prevalence of HIV and hepatitis B virus among pregnant women in Luanda (Angola): geospatial distribution and its association with socio-demographic and clinical-obstetric determinants

Ejemplares similares