A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.

Wound healing is a process driven by cells. The ability of cells to sense mechanical stimuli from the extracellular matrix that surrounds them is used to regulate the forces that cells exert on the tissue. Stresses exerted by cells play a central role in wound contraction and have been broadly model...

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Autores principales:	Clara Valero, Etelvina Javierre, José Manuel García-Aznar, María José Gómez-Benito
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a70009959ca408f989c05d03420c535
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spelling	oai:doaj.org-article:8a70009959ca408f989c05d03420c5352021-11-18T08:25:42ZA cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.1932-620310.1371/journal.pone.0092774https://doaj.org/article/8a70009959ca408f989c05d03420c5352014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24681636/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Wound healing is a process driven by cells. The ability of cells to sense mechanical stimuli from the extracellular matrix that surrounds them is used to regulate the forces that cells exert on the tissue. Stresses exerted by cells play a central role in wound contraction and have been broadly modelled. Traditionally, these stresses are assumed to be dependent on variables such as the extracellular matrix and cell or collagen densities. However, we postulate that cells are able to regulate the healing process through a mechanosensing mechanism regulated by the contraction that they exert. We propose that cells adjust the contraction level to determine the tissue functions regulating all main activities, such as proliferation, differentiation and matrix production. Hence, a closed-regulatory feedback loop is proposed between contraction and tissue formation. The model consists of a system of partial differential equations that simulates the evolution of fibroblasts, myofibroblasts, collagen and a generic growth factor, as well as the deformation of the extracellular matrix. This model is able to predict the wound healing outcome without requiring the addition of phenomenological laws to describe the time-dependent contraction evolution. We have reproduced two in vivo experiments to evaluate the predictive capacity of the model, and we conclude that there is feedback between the level of cell contraction and the tissue regenerated in the wound.Clara ValeroEtelvina JavierreEtelvina JavierreJosé Manuel García-AznarMaría José Gómez-BenitoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e92774 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clara Valero Etelvina Javierre Etelvina Javierre José Manuel García-Aznar María José Gómez-Benito A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
description	Wound healing is a process driven by cells. The ability of cells to sense mechanical stimuli from the extracellular matrix that surrounds them is used to regulate the forces that cells exert on the tissue. Stresses exerted by cells play a central role in wound contraction and have been broadly modelled. Traditionally, these stresses are assumed to be dependent on variables such as the extracellular matrix and cell or collagen densities. However, we postulate that cells are able to regulate the healing process through a mechanosensing mechanism regulated by the contraction that they exert. We propose that cells adjust the contraction level to determine the tissue functions regulating all main activities, such as proliferation, differentiation and matrix production. Hence, a closed-regulatory feedback loop is proposed between contraction and tissue formation. The model consists of a system of partial differential equations that simulates the evolution of fibroblasts, myofibroblasts, collagen and a generic growth factor, as well as the deformation of the extracellular matrix. This model is able to predict the wound healing outcome without requiring the addition of phenomenological laws to describe the time-dependent contraction evolution. We have reproduced two in vivo experiments to evaluate the predictive capacity of the model, and we conclude that there is feedback between the level of cell contraction and the tissue regenerated in the wound.
format	article
author	Clara Valero Etelvina Javierre Etelvina Javierre José Manuel García-Aznar María José Gómez-Benito
author_facet	Clara Valero Etelvina Javierre Etelvina Javierre José Manuel García-Aznar María José Gómez-Benito
author_sort	Clara Valero
title	A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
title_short	A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
title_full	A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
title_fullStr	A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
title_full_unstemmed	A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
title_sort	cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8a70009959ca408f989c05d03420c535
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A cell-regulatory mechanism involving feedback between contraction and tissue formation guides wound healing progression.

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