Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress
Anaplastic large cell lymphoma is characterized by an NPM–ALK fusion but the cell of origin for this cancer is unclear. Here, the authors show that, in an NPM–ALK mouse model, the tumours likely arise from early thmyocytes and require an initial burst of TCR signalling for initiation.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8a701b4d78ae4645840aae9ec06e39b7 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8a701b4d78ae4645840aae9ec06e39b7 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8a701b4d78ae4645840aae9ec06e39b72021-12-02T16:57:59ZAnaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress10.1038/ncomms100872041-1723https://doaj.org/article/8a701b4d78ae4645840aae9ec06e39b72016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10087https://doaj.org/toc/2041-1723Anaplastic large cell lymphoma is characterized by an NPM–ALK fusion but the cell of origin for this cancer is unclear. Here, the authors show that, in an NPM–ALK mouse model, the tumours likely arise from early thmyocytes and require an initial burst of TCR signalling for initiation.Tim I. M. MalcolmPatrick VillareseCamilla J. FairbairnLaurence LamantAmélie TrinquandC. Elizabeth HookG. A. Amos BurkeLaurence BrugièresKatherine HughesDominique PayetOlaf MerkelAna-Iris SchieferIbraheem AshankytyShahid MianMariusz WasikMartin TurnerLukas KennerVahid AsnafiElizabeth MacintyreSuzanne D. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tim I. M. Malcolm Patrick Villarese Camilla J. Fairbairn Laurence Lamant Amélie Trinquand C. Elizabeth Hook G. A. Amos Burke Laurence Brugières Katherine Hughes Dominique Payet Olaf Merkel Ana-Iris Schiefer Ibraheem Ashankyty Shahid Mian Mariusz Wasik Martin Turner Lukas Kenner Vahid Asnafi Elizabeth Macintyre Suzanne D. Turner Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |
| description |
Anaplastic large cell lymphoma is characterized by an NPM–ALK fusion but the cell of origin for this cancer is unclear. Here, the authors show that, in an NPM–ALK mouse model, the tumours likely arise from early thmyocytes and require an initial burst of TCR signalling for initiation. |
| format |
article |
| author |
Tim I. M. Malcolm Patrick Villarese Camilla J. Fairbairn Laurence Lamant Amélie Trinquand C. Elizabeth Hook G. A. Amos Burke Laurence Brugières Katherine Hughes Dominique Payet Olaf Merkel Ana-Iris Schiefer Ibraheem Ashankyty Shahid Mian Mariusz Wasik Martin Turner Lukas Kenner Vahid Asnafi Elizabeth Macintyre Suzanne D. Turner |
| author_facet |
Tim I. M. Malcolm Patrick Villarese Camilla J. Fairbairn Laurence Lamant Amélie Trinquand C. Elizabeth Hook G. A. Amos Burke Laurence Brugières Katherine Hughes Dominique Payet Olaf Merkel Ana-Iris Schiefer Ibraheem Ashankyty Shahid Mian Mariusz Wasik Martin Turner Lukas Kenner Vahid Asnafi Elizabeth Macintyre Suzanne D. Turner |
| author_sort |
Tim I. M. Malcolm |
| title |
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |
| title_short |
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |
| title_full |
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |
| title_fullStr |
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |
| title_full_unstemmed |
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress |
| title_sort |
anaplastic large cell lymphoma arises in thymocytes and requires transient tcr expression for thymic egress |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/8a701b4d78ae4645840aae9ec06e39b7 |
| work_keys_str_mv |
AT timimmalcolm anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT patrickvillarese anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT camillajfairbairn anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT laurencelamant anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT amelietrinquand anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT celizabethhook anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT gaamosburke anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT laurencebrugieres anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT katherinehughes anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT dominiquepayet anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT olafmerkel anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT anairisschiefer anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT ibraheemashankyty anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT shahidmian anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT mariuszwasik anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT martinturner anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT lukaskenner anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT vahidasnafi anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT elizabethmacintyre anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress AT suzannedturner anaplasticlargecelllymphomaarisesinthymocytesandrequirestransienttcrexpressionforthymicegress |
| _version_ |
1718382398506270720 |