DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes

The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress resistance and longevity promoting genes. Here the authors show that transcriptional initiation at many DAF-16/FOXO target genes requires the dephosphorylation of SPT-5 by P...

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Autores principales:	Ilke Sen, Xin Zhou, Alexey Chernobrovkin, Nataly Puerta-Cavanzo, Takaharu Kanno, Jérôme Salignon, Andrea Stoehr, Xin-Xuan Lin, Bora Baskaner, Simone Brandenburg, Camilla Björkegren, Roman A. Zubarev, Christian G. Riedel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a70884b9ec74e81afa962b134fef5ad
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spelling	oai:doaj.org-article:8a70884b9ec74e81afa962b134fef5ad2021-12-02T17:31:55ZDAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes10.1038/s41467-019-13931-72041-1723https://doaj.org/article/8a70884b9ec74e81afa962b134fef5ad2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13931-7https://doaj.org/toc/2041-1723The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress resistance and longevity promoting genes. Here the authors show that transcriptional initiation at many DAF-16/FOXO target genes requires the dephosphorylation of SPT-5 by Protein Phosphatase 4.Ilke SenXin ZhouAlexey ChernobrovkinNataly Puerta-CavanzoTakaharu KannoJérôme SalignonAndrea StoehrXin-Xuan LinBora BaskanerSimone BrandenburgCamilla BjörkegrenRoman A. ZubarevChristian G. RiedelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilke Sen Xin Zhou Alexey Chernobrovkin Nataly Puerta-Cavanzo Takaharu Kanno Jérôme Salignon Andrea Stoehr Xin-Xuan Lin Bora Baskaner Simone Brandenburg Camilla Björkegren Roman A. Zubarev Christian G. Riedel DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
description	The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress resistance and longevity promoting genes. Here the authors show that transcriptional initiation at many DAF-16/FOXO target genes requires the dephosphorylation of SPT-5 by Protein Phosphatase 4.
format	article
author	Ilke Sen Xin Zhou Alexey Chernobrovkin Nataly Puerta-Cavanzo Takaharu Kanno Jérôme Salignon Andrea Stoehr Xin-Xuan Lin Bora Baskaner Simone Brandenburg Camilla Björkegren Roman A. Zubarev Christian G. Riedel
author_facet	Ilke Sen Xin Zhou Alexey Chernobrovkin Nataly Puerta-Cavanzo Takaharu Kanno Jérôme Salignon Andrea Stoehr Xin-Xuan Lin Bora Baskaner Simone Brandenburg Camilla Björkegren Roman A. Zubarev Christian G. Riedel
author_sort	Ilke Sen
title	DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
title_short	DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
title_full	DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
title_fullStr	DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
title_full_unstemmed	DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
title_sort	daf-16/foxo requires protein phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a70884b9ec74e81afa962b134fef5ad
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DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes

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