Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity
This is an observational study of interstitial glucose (IG) concentrations, IG variability and dietary intake under free-living conditions in 46 females with obesity but without diabetes. We used continuous glucose monitoring, open-ended food recording and step monitoring during regular dietary inta...
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MDPI AG
2021
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oai:doaj.org-article:8a7162a23fb2442dab86548c8f44652b2021-11-25T18:33:12ZLower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity10.3390/nu131136872072-6643https://doaj.org/article/8a7162a23fb2442dab86548c8f44652b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3687https://doaj.org/toc/2072-6643This is an observational study of interstitial glucose (IG) concentrations, IG variability and dietary intake under free-living conditions in 46 females with obesity but without diabetes. We used continuous glucose monitoring, open-ended food recording and step monitoring during regular dietary intake followed by a low-energy diet (LED). Thirty-nine participants completed both study periods. The mean BMI at baseline was 43.6 ± 6.2 kg/m<sup>2</sup>. Three weeks of LED resulted in a mean weight loss of 5.2% with a significant reduction in diurnal IG concentration but with greater glycemic variability observed during LED. The mean 24 h IG concentration decreased from 5.8 ± 0.5 mmol/L during the regular diet period to 5.4 ± 0.5 mmol/L (<i>p</i> < 0.001) during LED, while the mean amplitude of glycemic excursion increased from 1.5 ± 0.7 to 1.7 ± 0.7 mmol/L (<i>p</i> = 0.031). The positive incremental area under the curve at breakfast was significantly larger for LED compared to regular diet. The daily fiber intake and the glycemic index of breakfast meals were significantly associated with the glycemic variability during regular dietary intake. In conclusion, the 24 h mean IG concentration was lower but with more pronounced glycemic variability during LED compared to a regular diet.Inger NilsenAgneta AnderssonAnna LaureniusJohanna OsterbergMagnus SundbomArvo HaenniMDPI AGarticleobesitylow-energy dietdietary fiberglycemic indexopen-ended food recordcontinuous glucose monitoringNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3687, p 3687 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
obesity low-energy diet dietary fiber glycemic index open-ended food record continuous glucose monitoring Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
obesity low-energy diet dietary fiber glycemic index open-ended food record continuous glucose monitoring Nutrition. Foods and food supply TX341-641 Inger Nilsen Agneta Andersson Anna Laurenius Johanna Osterberg Magnus Sundbom Arvo Haenni Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity |
| description |
This is an observational study of interstitial glucose (IG) concentrations, IG variability and dietary intake under free-living conditions in 46 females with obesity but without diabetes. We used continuous glucose monitoring, open-ended food recording and step monitoring during regular dietary intake followed by a low-energy diet (LED). Thirty-nine participants completed both study periods. The mean BMI at baseline was 43.6 ± 6.2 kg/m<sup>2</sup>. Three weeks of LED resulted in a mean weight loss of 5.2% with a significant reduction in diurnal IG concentration but with greater glycemic variability observed during LED. The mean 24 h IG concentration decreased from 5.8 ± 0.5 mmol/L during the regular diet period to 5.4 ± 0.5 mmol/L (<i>p</i> < 0.001) during LED, while the mean amplitude of glycemic excursion increased from 1.5 ± 0.7 to 1.7 ± 0.7 mmol/L (<i>p</i> = 0.031). The positive incremental area under the curve at breakfast was significantly larger for LED compared to regular diet. The daily fiber intake and the glycemic index of breakfast meals were significantly associated with the glycemic variability during regular dietary intake. In conclusion, the 24 h mean IG concentration was lower but with more pronounced glycemic variability during LED compared to a regular diet. |
| format |
article |
| author |
Inger Nilsen Agneta Andersson Anna Laurenius Johanna Osterberg Magnus Sundbom Arvo Haenni |
| author_facet |
Inger Nilsen Agneta Andersson Anna Laurenius Johanna Osterberg Magnus Sundbom Arvo Haenni |
| author_sort |
Inger Nilsen |
| title |
Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity |
| title_short |
Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity |
| title_full |
Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity |
| title_fullStr |
Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity |
| title_full_unstemmed |
Lower Interstitial Glucose Concentrations but Higher Glucose Variability during Low-Energy Diet Compared to Regular Diet—An Observational Study in Females with Obesity |
| title_sort |
lower interstitial glucose concentrations but higher glucose variability during low-energy diet compared to regular diet—an observational study in females with obesity |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/8a7162a23fb2442dab86548c8f44652b |
| work_keys_str_mv |
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1718411030083665920 |