T-cells produce acidic niches in lymph nodes to suppress their own effector functions

T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells, but does not alter their activation by antigen-pr...

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Autores principales:	Hao Wu, Veronica Estrella, Matthew Beatty, Dominique Abrahams, Asmaa El-Kenawi, Shonagh Russell, Arig Ibrahim-Hashim, Dario Livio Longo, Yana K. Reshetnyak, Anna Moshnikova, Oleg A. Andreev, Kimberly Luddy, Mehdi Damaghi, Krithika Kodumudi, Smitha R. Pillai, Pedro Enriquez-Navas, Shari Pilon-Thomas, Pawel Swietach, Robert J. Gillies
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc
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spelling	oai:doaj.org-article:8a725d35fbca44839f00a263e2a935bc2021-12-02T16:45:30ZT-cells produce acidic niches in lymph nodes to suppress their own effector functions10.1038/s41467-020-17756-72041-1723https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17756-7https://doaj.org/toc/2041-1723T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells, but does not alter their activation by antigen-presenting cells.Hao WuVeronica EstrellaMatthew BeattyDominique AbrahamsAsmaa El-KenawiShonagh RussellArig Ibrahim-HashimDario Livio LongoYana K. ReshetnyakAnna MoshnikovaOleg A. AndreevKimberly LuddyMehdi DamaghiKrithika KodumudiSmitha R. PillaiPedro Enriquez-NavasShari Pilon-ThomasPawel SwietachRobert J. GilliesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Wu Veronica Estrella Matthew Beatty Dominique Abrahams Asmaa El-Kenawi Shonagh Russell Arig Ibrahim-Hashim Dario Livio Longo Yana K. Reshetnyak Anna Moshnikova Oleg A. Andreev Kimberly Luddy Mehdi Damaghi Krithika Kodumudi Smitha R. Pillai Pedro Enriquez-Navas Shari Pilon-Thomas Pawel Swietach Robert J. Gillies T-cells produce acidic niches in lymph nodes to suppress their own effector functions
description	T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells, but does not alter their activation by antigen-presenting cells.
format	article
author	Hao Wu Veronica Estrella Matthew Beatty Dominique Abrahams Asmaa El-Kenawi Shonagh Russell Arig Ibrahim-Hashim Dario Livio Longo Yana K. Reshetnyak Anna Moshnikova Oleg A. Andreev Kimberly Luddy Mehdi Damaghi Krithika Kodumudi Smitha R. Pillai Pedro Enriquez-Navas Shari Pilon-Thomas Pawel Swietach Robert J. Gillies
author_facet	Hao Wu Veronica Estrella Matthew Beatty Dominique Abrahams Asmaa El-Kenawi Shonagh Russell Arig Ibrahim-Hashim Dario Livio Longo Yana K. Reshetnyak Anna Moshnikova Oleg A. Andreev Kimberly Luddy Mehdi Damaghi Krithika Kodumudi Smitha R. Pillai Pedro Enriquez-Navas Shari Pilon-Thomas Pawel Swietach Robert J. Gillies
author_sort	Hao Wu
title	T-cells produce acidic niches in lymph nodes to suppress their own effector functions
title_short	T-cells produce acidic niches in lymph nodes to suppress their own effector functions
title_full	T-cells produce acidic niches in lymph nodes to suppress their own effector functions
title_fullStr	T-cells produce acidic niches in lymph nodes to suppress their own effector functions
title_full_unstemmed	T-cells produce acidic niches in lymph nodes to suppress their own effector functions
title_sort	t-cells produce acidic niches in lymph nodes to suppress their own effector functions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc
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T-cells produce acidic niches in lymph nodes to suppress their own effector functions

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