Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

Dopamine receptor agonists are used for the treatment of various psychiatric diseases. Here, the authors screen approximately three million compounds and identify a novel class of D1R agonists that do not have a catechol scaffold and possess promising pharmacokinetic properties.

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Autores principales:	David L. Gray, John A. Allen, Scot Mente, Rebecca E. O’Connor, George J. DeMarco, Ivan Efremov, Patrick Tierney, Dmitri Volfson, Jennifer Davoren, Edward Guilmette, Michelle Salafia, Rouba Kozak, Michael D. Ehlers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a74eb3e0a2d4c1fa0ce2b3e319fdc9f
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spelling	oai:doaj.org-article:8a74eb3e0a2d4c1fa0ce2b3e319fdc9f2021-12-02T17:32:34ZImpaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor10.1038/s41467-017-02776-72041-1723https://doaj.org/article/8a74eb3e0a2d4c1fa0ce2b3e319fdc9f2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02776-7https://doaj.org/toc/2041-1723Dopamine receptor agonists are used for the treatment of various psychiatric diseases. Here, the authors screen approximately three million compounds and identify a novel class of D1R agonists that do not have a catechol scaffold and possess promising pharmacokinetic properties.David L. GrayJohn A. AllenScot MenteRebecca E. O’ConnorGeorge J. DeMarcoIvan EfremovPatrick TierneyDmitri VolfsonJennifer DavorenEdward GuilmetteMichelle SalafiaRouba KozakMichael D. EhlersNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David L. Gray John A. Allen Scot Mente Rebecca E. O’Connor George J. DeMarco Ivan Efremov Patrick Tierney Dmitri Volfson Jennifer Davoren Edward Guilmette Michelle Salafia Rouba Kozak Michael D. Ehlers Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
description	Dopamine receptor agonists are used for the treatment of various psychiatric diseases. Here, the authors screen approximately three million compounds and identify a novel class of D1R agonists that do not have a catechol scaffold and possess promising pharmacokinetic properties.
format	article
author	David L. Gray John A. Allen Scot Mente Rebecca E. O’Connor George J. DeMarco Ivan Efremov Patrick Tierney Dmitri Volfson Jennifer Davoren Edward Guilmette Michelle Salafia Rouba Kozak Michael D. Ehlers
author_facet	David L. Gray John A. Allen Scot Mente Rebecca E. O’Connor George J. DeMarco Ivan Efremov Patrick Tierney Dmitri Volfson Jennifer Davoren Edward Guilmette Michelle Salafia Rouba Kozak Michael D. Ehlers
author_sort	David L. Gray
title	Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
title_short	Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
title_full	Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
title_fullStr	Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
title_full_unstemmed	Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
title_sort	impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the d1 dopamine receptor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8a74eb3e0a2d4c1fa0ce2b3e319fdc9f
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Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

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