CBD, a precursor of THC in e-cigarettes

Abstract The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effec...

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Autores principales:	Zsuzsanna Czégény, Gréta Nagy, Bence Babinszki, Ákos Bajtel, Zoltán Sebestyén, Tivadar Kiss, Boglárka Csupor-Löffler, Barbara Tóth, Dezső Csupor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a7552e8882f43a194e4903428e3b9a8
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spelling	oai:doaj.org-article:8a7552e8882f43a194e4903428e3b9a82021-12-02T13:41:34ZCBD, a precursor of THC in e-cigarettes10.1038/s41598-021-88389-z2045-2322https://doaj.org/article/8a7552e8882f43a194e4903428e3b9a82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88389-zhttps://doaj.org/toc/2045-2322Abstract The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250–400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC–MS. Depending on the temperature and atmosphere, 25–52% of CBD was transformed into other chemical substances: Δ9-THC, Δ8-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC was the main pyrolysis product at all temperatures under both oxidative and inert conditions. Our results point out that CBD in e-cigarettes can be considered as a precursor of THC, thus it bears all the dangers related to this psychoactive compound. Our findings are fundamental contributions to the safety profile of CBD-based e-cigarettes.Zsuzsanna CzégényGréta NagyBence BabinszkiÁkos BajtelZoltán SebestyénTivadar KissBoglárka Csupor-LöfflerBarbara TóthDezső CsuporNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zsuzsanna Czégény Gréta Nagy Bence Babinszki Ákos Bajtel Zoltán Sebestyén Tivadar Kiss Boglárka Csupor-Löffler Barbara Tóth Dezső Csupor CBD, a precursor of THC in e-cigarettes
description	Abstract The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250–400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC–MS. Depending on the temperature and atmosphere, 25–52% of CBD was transformed into other chemical substances: Δ9-THC, Δ8-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC was the main pyrolysis product at all temperatures under both oxidative and inert conditions. Our results point out that CBD in e-cigarettes can be considered as a precursor of THC, thus it bears all the dangers related to this psychoactive compound. Our findings are fundamental contributions to the safety profile of CBD-based e-cigarettes.
format	article
author	Zsuzsanna Czégény Gréta Nagy Bence Babinszki Ákos Bajtel Zoltán Sebestyén Tivadar Kiss Boglárka Csupor-Löffler Barbara Tóth Dezső Csupor
author_facet	Zsuzsanna Czégény Gréta Nagy Bence Babinszki Ákos Bajtel Zoltán Sebestyén Tivadar Kiss Boglárka Csupor-Löffler Barbara Tóth Dezső Csupor
author_sort	Zsuzsanna Czégény
title	CBD, a precursor of THC in e-cigarettes
title_short	CBD, a precursor of THC in e-cigarettes
title_full	CBD, a precursor of THC in e-cigarettes
title_fullStr	CBD, a precursor of THC in e-cigarettes
title_full_unstemmed	CBD, a precursor of THC in e-cigarettes
title_sort	cbd, a precursor of thc in e-cigarettes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a7552e8882f43a194e4903428e3b9a8
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CBD, a precursor of THC in e-cigarettes

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