Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study

Abstract Increased prevalence of sleep disorders has been found in patients with functional dyspepsia; however, direction of causality remains unclear. Our aim was to compare the risk of incident functional dyspepsia between patients with and without sleep disturbance from a large population-based s...

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Autores principales:	Hsu-Han Su, Fung-Chang Sung, Kai-Liang Kao, Shu-Chin Chen, Chen-Ju Lin, Shu-I Wu, Cheng-Li Lin, Robert Stewart, Yi-Shin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a76a303ee0148d5a306409dd7f236a8
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spelling	oai:doaj.org-article:8a76a303ee0148d5a306409dd7f236a82021-12-02T15:15:04ZRelative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study10.1038/s41598-021-98169-42045-2322https://doaj.org/article/8a76a303ee0148d5a306409dd7f236a82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98169-4https://doaj.org/toc/2045-2322Abstract Increased prevalence of sleep disorders has been found in patients with functional dyspepsia; however, direction of causality remains unclear. Our aim was to compare the risk of incident functional dyspepsia between patients with and without sleep disturbance from a large population-based sample. Utilizing a nation-wide health insurance administrative dataset, we assembled an 11-year historic cohort study to compare subsequent incidence of diagnosed functional dyspepsia between adult patients with any diagnosis of sleep disturbance and age- and gender-matched controls. Hazard ratios adjusted for other relevant comorbidities and medications were calculated using Cox regression models. 45,310 patients with sleep disorder and 90,620 controls were compared. Patients with sleep apnea had a 3.3-fold (95% confidence interval: 2.82 ~ 3.89) increased hazard of functional dyspepsia compared with controls. This increased risk persisted regardless of previously diagnosed depression coexisted. Sleep disturbance was associated with an increased risk of subsequent functional dyspepsia. Potential mechanisms are discussed.Hsu-Han SuFung-Chang SungKai-Liang KaoShu-Chin ChenChen-Ju LinShu-I WuCheng-Li LinRobert StewartYi-Shin ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsu-Han Su Fung-Chang Sung Kai-Liang Kao Shu-Chin Chen Chen-Ju Lin Shu-I Wu Cheng-Li Lin Robert Stewart Yi-Shin Chen Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
description	Abstract Increased prevalence of sleep disorders has been found in patients with functional dyspepsia; however, direction of causality remains unclear. Our aim was to compare the risk of incident functional dyspepsia between patients with and without sleep disturbance from a large population-based sample. Utilizing a nation-wide health insurance administrative dataset, we assembled an 11-year historic cohort study to compare subsequent incidence of diagnosed functional dyspepsia between adult patients with any diagnosis of sleep disturbance and age- and gender-matched controls. Hazard ratios adjusted for other relevant comorbidities and medications were calculated using Cox regression models. 45,310 patients with sleep disorder and 90,620 controls were compared. Patients with sleep apnea had a 3.3-fold (95% confidence interval: 2.82 ~ 3.89) increased hazard of functional dyspepsia compared with controls. This increased risk persisted regardless of previously diagnosed depression coexisted. Sleep disturbance was associated with an increased risk of subsequent functional dyspepsia. Potential mechanisms are discussed.
format	article
author	Hsu-Han Su Fung-Chang Sung Kai-Liang Kao Shu-Chin Chen Chen-Ju Lin Shu-I Wu Cheng-Li Lin Robert Stewart Yi-Shin Chen
author_facet	Hsu-Han Su Fung-Chang Sung Kai-Liang Kao Shu-Chin Chen Chen-Ju Lin Shu-I Wu Cheng-Li Lin Robert Stewart Yi-Shin Chen
author_sort	Hsu-Han Su
title	Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
title_short	Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
title_full	Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
title_fullStr	Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
title_full_unstemmed	Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
title_sort	relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a76a303ee0148d5a306409dd7f236a8
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Relative risk of functional dyspepsia in patients with sleep disturbance: a population-based cohort study

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