Association between family history and lung cancer risk among Chinese women in Singapore

Abstract Risk factors of lung cancer unrelated to smoking are not well-studied, especially among women. Family history has been shown to play a role in predisposing individuals to lung cancer, but this relationship has not been investigated in the Southeast Asian population. A total of 1159 women we...

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Autores principales:	Xin Yin, Cheryl Pui Yi Chan, Adeline Seow, Wai-Ping Yau, Wei Jie Seow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a7814487899430db21eddfef62a5d62
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spelling	oai:doaj.org-article:8a7814487899430db21eddfef62a5d622021-11-14T12:21:00ZAssociation between family history and lung cancer risk among Chinese women in Singapore10.1038/s41598-021-00929-92045-2322https://doaj.org/article/8a7814487899430db21eddfef62a5d622021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00929-9https://doaj.org/toc/2045-2322Abstract Risk factors of lung cancer unrelated to smoking are not well-studied, especially among women. Family history has been shown to play a role in predisposing individuals to lung cancer, but this relationship has not been investigated in the Southeast Asian population. A total of 1159 women were recruited in a case–control study conducted in public hospitals in Singapore from 2005 to 2008. After excluding participants with incomplete family history information, 374 cases and 785 controls remained in the final analysis. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression, adjusting for potential confounders. Overall, family history of lung cancer was associated with a higher risk for lung cancer (aOR 2.08, 95% CI 1.25–3.47). When stratified by smoking status, a significant association was observed among never-smokers (aOR 2.78, 95% CI 1.57–4.90). Further stratification by fruit consumption identified a significant association between family history of lung cancer and higher risk of lung cancer among never-smokers who had low fruit consumption (aOR 3.09, 95% CI 1.37–7.01). Our findings suggest that family history of lung cancer is a significant risk factor for lung cancer in Singaporean Chinese women, especially among never-smokers.Xin YinCheryl Pui Yi ChanAdeline SeowWai-Ping YauWei Jie SeowNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Yin Cheryl Pui Yi Chan Adeline Seow Wai-Ping Yau Wei Jie Seow Association between family history and lung cancer risk among Chinese women in Singapore
description	Abstract Risk factors of lung cancer unrelated to smoking are not well-studied, especially among women. Family history has been shown to play a role in predisposing individuals to lung cancer, but this relationship has not been investigated in the Southeast Asian population. A total of 1159 women were recruited in a case–control study conducted in public hospitals in Singapore from 2005 to 2008. After excluding participants with incomplete family history information, 374 cases and 785 controls remained in the final analysis. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression, adjusting for potential confounders. Overall, family history of lung cancer was associated with a higher risk for lung cancer (aOR 2.08, 95% CI 1.25–3.47). When stratified by smoking status, a significant association was observed among never-smokers (aOR 2.78, 95% CI 1.57–4.90). Further stratification by fruit consumption identified a significant association between family history of lung cancer and higher risk of lung cancer among never-smokers who had low fruit consumption (aOR 3.09, 95% CI 1.37–7.01). Our findings suggest that family history of lung cancer is a significant risk factor for lung cancer in Singaporean Chinese women, especially among never-smokers.
format	article
author	Xin Yin Cheryl Pui Yi Chan Adeline Seow Wai-Ping Yau Wei Jie Seow
author_facet	Xin Yin Cheryl Pui Yi Chan Adeline Seow Wai-Ping Yau Wei Jie Seow
author_sort	Xin Yin
title	Association between family history and lung cancer risk among Chinese women in Singapore
title_short	Association between family history and lung cancer risk among Chinese women in Singapore
title_full	Association between family history and lung cancer risk among Chinese women in Singapore
title_fullStr	Association between family history and lung cancer risk among Chinese women in Singapore
title_full_unstemmed	Association between family history and lung cancer risk among Chinese women in Singapore
title_sort	association between family history and lung cancer risk among chinese women in singapore
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a7814487899430db21eddfef62a5d62
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Association between family history and lung cancer risk among Chinese women in Singapore

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