Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia

Purpose: To investigate the changes in the macular microvascular structure after anti-vascular endothelial growth factor (anti-VEGF) treatment in retinal vein occlusion (RVO) patients with and without macular ischemia.Methods: A total of 39 patients were divided into the macular ischemia group (n =...

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Autores principales:	Ziyi Zhu, Yongan Meng, Igor Kozak, Manyun Xie, Youling Liang, Bin Yan, Liang Zhou, Pingbo Ouyang, Xiaoxi Yao, Jing Luo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anti-VEGF treatment macular ischemia OCTA ischemic index RVO vessel density (VD) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8a796f95f1d24a2087e9f27c51af304f
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spelling	oai:doaj.org-article:8a796f95f1d24a2087e9f27c51af304f2021-11-12T04:36:04ZMicrovascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia2296-858X10.3389/fmed.2021.737537https://doaj.org/article/8a796f95f1d24a2087e9f27c51af304f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.737537/fullhttps://doaj.org/toc/2296-858XPurpose: To investigate the changes in the macular microvascular structure after anti-vascular endothelial growth factor (anti-VEGF) treatment in retinal vein occlusion (RVO) patients with and without macular ischemia.Methods: A total of 39 patients were divided into the macular ischemia group (n = 22) and the nonischemia group (n = 17) at baseline. All the patients received an intravitreal injection of ranibizumab with a 3+ pro re nata (PRN) regimen. The foveal avascular zone (FAZ) areas, macular vessel density (VD), and macular ischemic index (ISI) were evaluated at baseline and 3 and 6 months after treatment.Results: After treatment, some patients in the macular ischemia group achieved obvious reperfusion in macular nonperfusion areas. The VD and macular ISI improved in RVO patients, but the changes in VD and macular ISI were different in the two groups. The improvement of best corrected visual acuity (BCVA) was positively correlated with the improvement of macular perfusion status. Macular perfusion remained stable in most patients in RVO and only one patient had macular ischemia aggravation.Conclusion: The macular microvascular structures were stable in most RVO patients after anti-VEGF treatment. At the same time, some patients with macular ischemia presented reperfusion in macular nonperfusion areas, and still a few patients presented aggravated macular ischemia. Macular ISI is a good way to evaluate macular perfusion status in RVO compared to VD.Ziyi ZhuYongan MengIgor KozakManyun XieYouling LiangBin YanLiang ZhouPingbo OuyangXiaoxi YaoJing LuoJing LuoFrontiers Media S.A.articleanti-VEGF treatmentmacular ischemiaOCTAischemic indexRVOvessel density (VD)Medicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-VEGF treatment macular ischemia OCTA ischemic index RVO vessel density (VD) Medicine (General) R5-920
spellingShingle	anti-VEGF treatment macular ischemia OCTA ischemic index RVO vessel density (VD) Medicine (General) R5-920 Ziyi Zhu Yongan Meng Igor Kozak Manyun Xie Youling Liang Bin Yan Liang Zhou Pingbo Ouyang Xiaoxi Yao Jing Luo Jing Luo Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
description	Purpose: To investigate the changes in the macular microvascular structure after anti-vascular endothelial growth factor (anti-VEGF) treatment in retinal vein occlusion (RVO) patients with and without macular ischemia.Methods: A total of 39 patients were divided into the macular ischemia group (n = 22) and the nonischemia group (n = 17) at baseline. All the patients received an intravitreal injection of ranibizumab with a 3+ pro re nata (PRN) regimen. The foveal avascular zone (FAZ) areas, macular vessel density (VD), and macular ischemic index (ISI) were evaluated at baseline and 3 and 6 months after treatment.Results: After treatment, some patients in the macular ischemia group achieved obvious reperfusion in macular nonperfusion areas. The VD and macular ISI improved in RVO patients, but the changes in VD and macular ISI were different in the two groups. The improvement of best corrected visual acuity (BCVA) was positively correlated with the improvement of macular perfusion status. Macular perfusion remained stable in most patients in RVO and only one patient had macular ischemia aggravation.Conclusion: The macular microvascular structures were stable in most RVO patients after anti-VEGF treatment. At the same time, some patients with macular ischemia presented reperfusion in macular nonperfusion areas, and still a few patients presented aggravated macular ischemia. Macular ISI is a good way to evaluate macular perfusion status in RVO compared to VD.
format	article
author	Ziyi Zhu Yongan Meng Igor Kozak Manyun Xie Youling Liang Bin Yan Liang Zhou Pingbo Ouyang Xiaoxi Yao Jing Luo Jing Luo
author_facet	Ziyi Zhu Yongan Meng Igor Kozak Manyun Xie Youling Liang Bin Yan Liang Zhou Pingbo Ouyang Xiaoxi Yao Jing Luo Jing Luo
author_sort	Ziyi Zhu
title	Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
title_short	Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
title_full	Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
title_fullStr	Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
title_full_unstemmed	Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
title_sort	microvascular structure changes after intravitreal ranibizumab injection in retinal vein occlusion patients with and without macular ischemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8a796f95f1d24a2087e9f27c51af304f
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Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia

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