Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice
Abstract Niemann-Pick disease Type C1 (NPC1) is a rare hereditary neurodegenerative disease. NPC1-patients suffer, amongst others, from ataxia, based on a loss of cerebellar Purkinje cells (PCs). Impaired expression/function of excitatory amino acid transporters (EAATs) are suspected of contributing...
Enregistré dans:
Auteurs principaux: | Michael Rabenstein, Franziska Peter, Arndt Rolfs, Moritz J. Frech |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/8a7a8cdad48c4320bb1096a908cfd2a0 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
par: Saša Peter, et autres
Publié: (2016) -
Optogenetic manipulation of cerebellar Purkinje cell activity in vivo.
par: Tadashi Tsubota, et autres
Publié: (2011) -
Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
par: Megumi Kaneko, et autres
Publié: (2011) -
Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
par: Daneck Lang-Ouellette, et autres
Publié: (2021) -
Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction
par: Aaron Sathyanesan, et autres
Publié: (2018)