Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control

Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control

Ribosome-associated quality control (RQC) pathways monitor and respond to stalling of the translating ribosome. Here the authors show that the ribosome associated RQC factor Hel2/ZNF598, an E3 ubiquitin ligase, generally interacts with mRNAs in the vicinity of stop codons.

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Autores principales: Marie-Luise Winz, Lauri Peil, Tomasz W. Turowski, Juri Rappsilber, David Tollervey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/8a7d0af30df44875ade6bb5b790e906b
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spelling oai:doaj.org-article:8a7d0af30df44875ade6bb5b790e906b2021-12-02T14:40:20ZMolecular interactions between Hel2 and RNA supporting ribosome-associated quality control10.1038/s41467-019-08382-z2041-1723https://doaj.org/article/8a7d0af30df44875ade6bb5b790e906b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08382-zhttps://doaj.org/toc/2041-1723Ribosome-associated quality control (RQC) pathways monitor and respond to stalling of the translating ribosome. Here the authors show that the ribosome associated RQC factor Hel2/ZNF598, an E3 ubiquitin ligase, generally interacts with mRNAs in the vicinity of stop codons.Marie-Luise WinzLauri PeilTomasz W. TurowskiJuri RappsilberDavid TollerveyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marie-Luise Winz
Lauri Peil
Tomasz W. Turowski
Juri Rappsilber
David Tollervey
Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
description Ribosome-associated quality control (RQC) pathways monitor and respond to stalling of the translating ribosome. Here the authors show that the ribosome associated RQC factor Hel2/ZNF598, an E3 ubiquitin ligase, generally interacts with mRNAs in the vicinity of stop codons.
format article
author Marie-Luise Winz
Lauri Peil
Tomasz W. Turowski
Juri Rappsilber
David Tollervey
author_facet Marie-Luise Winz
Lauri Peil
Tomasz W. Turowski
Juri Rappsilber
David Tollervey
author_sort Marie-Luise Winz
title Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
title_short Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
title_full Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
title_fullStr Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
title_full_unstemmed Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
title_sort molecular interactions between hel2 and rna supporting ribosome-associated quality control
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8a7d0af30df44875ade6bb5b790e906b
work_keys_str_mv AT marieluisewinz molecularinteractionsbetweenhel2andrnasupportingribosomeassociatedqualitycontrol
AT lauripeil molecularinteractionsbetweenhel2andrnasupportingribosomeassociatedqualitycontrol
AT tomaszwturowski molecularinteractionsbetweenhel2andrnasupportingribosomeassociatedqualitycontrol
AT jurirappsilber molecularinteractionsbetweenhel2andrnasupportingribosomeassociatedqualitycontrol
AT davidtollervey molecularinteractionsbetweenhel2andrnasupportingribosomeassociatedqualitycontrol
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