ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension

Objective: To determine the positive predictive value of beta Human Chorionic Gonadotrophin in early second trimester for predicting pregnancy induced hypertension. Study Design: Cross-sectional study. Place and Duration of Study: Department of Obstetrics and Gynaecology Combined Military Hos...

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Autores principales:	Nayab Afzal Chatha, Humaira Osman Jaffery, Saima Qamar, Nilofar Mustafa, Rizwana Kamran, Viqar Ashraf
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	β hcg positive predictive value pregnancy induced hypertension beta human chorionic gonadotropin (β-hcg) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v70i6.3452 https://doaj.org/article/8a7d30ef03ab4f839daffcddfd44ad72
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spelling	oai:doaj.org-article:8a7d30ef03ab4f839daffcddfd44ad722021-12-02T19:12:09ZASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertensionhttps://doi.org/10.51253/pafmj.v70i6.34520030-96482411-8842https://doaj.org/article/8a7d30ef03ab4f839daffcddfd44ad722020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3452https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the positive predictive value of beta Human Chorionic Gonadotrophin in early second trimester for predicting pregnancy induced hypertension. Study Design: Cross-sectional study. Place and Duration of Study: Department of Obstetrics and Gynaecology Combined Military Hospital, Lahore, from Jun 2017 to Nov 2017. Methodology: A total of 214 female pregnant patients met the criteria for inclusion in this study. Patients with beta human chorionic gonadotrophin (βHcg) levels ≥2 MoM were followed at 22, 26, 30 and 34 weeks of gestation. Blood pressure was monitored. Pregnancy induced hypertension (PIH) was labelled after 20 weeks (as per dating scan) of gestation in patients who did not have proteinuria (≥300 mg 24 hour urine sample) and had a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg (blood pressure readings taken at two separate points in time four hours apart). Results: Patients ranged between 18-35 years of age, with the mean age being 27.3 ± 4.3 years. Mean gestational age was observed to be 15.6 ± 1.8 weeks. Mean BMI was 23.8 ± 3.2 kg/m2. Out of 214 patients, 30 patients (14%) had beta human chorionic gonadotrophin level >2 MoM. Out of these 30 patients, 25 patients (83.3%) developed PIH. There were 100 primigravida (46.7%) and 114 multigravidas (53.3%). Beta human chorionic gonadotrophin in predicting pregnancy induced hypertension showed sensi-tivity of 96.1%, a specificity of 97.3%, with a PPV83.3%, a NPV 99.4% and diagnostic accuracy of 97.2%.Nayab Afzal ChathaHumaira Osman JafferySaima QamarNilofar MustafaRizwana KamranViqar AshrafArmy Medical College Rawalpindiarticleβ hcgpositive predictive valuepregnancy induced hypertensionbeta human chorionic gonadotropin (β-hcg)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1712-1716 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	β hcg positive predictive value pregnancy induced hypertension beta human chorionic gonadotropin (β-hcg) Medicine R Medicine (General) R5-920
spellingShingle	β hcg positive predictive value pregnancy induced hypertension beta human chorionic gonadotropin (β-hcg) Medicine R Medicine (General) R5-920 Nayab Afzal Chatha Humaira Osman Jaffery Saima Qamar Nilofar Mustafa Rizwana Kamran Viqar Ashraf ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension
description	Objective: To determine the positive predictive value of beta Human Chorionic Gonadotrophin in early second trimester for predicting pregnancy induced hypertension. Study Design: Cross-sectional study. Place and Duration of Study: Department of Obstetrics and Gynaecology Combined Military Hospital, Lahore, from Jun 2017 to Nov 2017. Methodology: A total of 214 female pregnant patients met the criteria for inclusion in this study. Patients with beta human chorionic gonadotrophin (βHcg) levels ≥2 MoM were followed at 22, 26, 30 and 34 weeks of gestation. Blood pressure was monitored. Pregnancy induced hypertension (PIH) was labelled after 20 weeks (as per dating scan) of gestation in patients who did not have proteinuria (≥300 mg 24 hour urine sample) and had a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg (blood pressure readings taken at two separate points in time four hours apart). Results: Patients ranged between 18-35 years of age, with the mean age being 27.3 ± 4.3 years. Mean gestational age was observed to be 15.6 ± 1.8 weeks. Mean BMI was 23.8 ± 3.2 kg/m2. Out of 214 patients, 30 patients (14%) had beta human chorionic gonadotrophin level >2 MoM. Out of these 30 patients, 25 patients (83.3%) developed PIH. There were 100 primigravida (46.7%) and 114 multigravidas (53.3%). Beta human chorionic gonadotrophin in predicting pregnancy induced hypertension showed sensi-tivity of 96.1%, a specificity of 97.3%, with a PPV83.3%, a NPV 99.4% and diagnostic accuracy of 97.2%.
format	article
author	Nayab Afzal Chatha Humaira Osman Jaffery Saima Qamar Nilofar Mustafa Rizwana Kamran Viqar Ashraf
author_facet	Nayab Afzal Chatha Humaira Osman Jaffery Saima Qamar Nilofar Mustafa Rizwana Kamran Viqar Ashraf
author_sort	Nayab Afzal Chatha
title	ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension
title_short	ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension
title_full	ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension
title_fullStr	ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension
title_full_unstemmed	ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension
title_sort	association of human chorionic gonadotrophin with pregnancy induced hypertension beta hcg and pregnancy induced hypertension
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doi.org/10.51253/pafmj.v70i6.3452 https://doaj.org/article/8a7d30ef03ab4f839daffcddfd44ad72
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ASSOCIATION OF HUMAN CHORIONIC GONADOTROPHIN WITH PREGNANCY INDUCED HYPERTENSION beta HCG and pregnancy induced hypertension

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