γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.

Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on h...

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Autores principales:	Jing-Shu Zhang, Da-Ming Li, Yue Ma, Ning He, Qing Gu, Feng-Shan Wang, Shu-Qing Jiang, Bing-Qing Chen, Jia-Ren Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a830fb3a0b94084ae6f04fbf323c081
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spelling	oai:doaj.org-article:8a830fb3a0b94084ae6f04fbf323c0812021-11-18T07:55:24Zγ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.1932-620310.1371/journal.pone.0057779https://doaj.org/article/8a830fb3a0b94084ae6f04fbf323c0812013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23469066/?tool=EBIhttps://doaj.org/toc/1932-6203Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on human colon cancer SW620 and HCT-8 cells. We showed that treatment with different concentrations of γ-tocotrienol resulted in a dose dependent inhibition of cell growth. Cell death induced by γ-tocotrienol was mediated by a paraptosis-like cell death in SW620 and HCT-8 cells. Real-time RT-PCR and western blot analyses showed that γ-tocotrienol inhibited the expression level of β-catenin, cyclin D1 and c-jun. These data suggest that a paraptosis-like cell death induced by γ-tocotrienol in SW620 cells is associated with the suppression of the Wnt signaling pathway, which offers a novel tool for treating apoptosis-resistance colon cancer.Jing-Shu ZhangDa-Ming LiYue MaNing HeQing GuFeng-Shan WangShu-Qing JiangBing-Qing ChenJia-Ren LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57779 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing-Shu Zhang Da-Ming Li Yue Ma Ning He Qing Gu Feng-Shan Wang Shu-Qing Jiang Bing-Qing Chen Jia-Ren Liu γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.
description	Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on human colon cancer SW620 and HCT-8 cells. We showed that treatment with different concentrations of γ-tocotrienol resulted in a dose dependent inhibition of cell growth. Cell death induced by γ-tocotrienol was mediated by a paraptosis-like cell death in SW620 and HCT-8 cells. Real-time RT-PCR and western blot analyses showed that γ-tocotrienol inhibited the expression level of β-catenin, cyclin D1 and c-jun. These data suggest that a paraptosis-like cell death induced by γ-tocotrienol in SW620 cells is associated with the suppression of the Wnt signaling pathway, which offers a novel tool for treating apoptosis-resistance colon cancer.
format	article
author	Jing-Shu Zhang Da-Ming Li Yue Ma Ning He Qing Gu Feng-Shan Wang Shu-Qing Jiang Bing-Qing Chen Jia-Ren Liu
author_facet	Jing-Shu Zhang Da-Ming Li Yue Ma Ning He Qing Gu Feng-Shan Wang Shu-Qing Jiang Bing-Qing Chen Jia-Ren Liu
author_sort	Jing-Shu Zhang
title	γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.
title_short	γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.
title_full	γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.
title_fullStr	γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.
title_full_unstemmed	γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.
title_sort	γ-tocotrienol induces paraptosis-like cell death in human colon carcinoma sw620 cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8a830fb3a0b94084ae6f04fbf323c081
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γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.

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