Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature

Objective. To discuss the influence of high-dose recombinant human growth hormone (rhGH) therapy on serum vitamin D and insulin-like growth factor-1 (IGF-1) levels in school-age children with idiopathic short stature (ISS). Method. A total of 103 school-age children with ISS were selected from June...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Juan Li, Xuehui Zhang, Shuyong Xie, Shuangshuang Feng, Min Niu
Formato: article
Lenguaje:EN
Publicado: Hindawi Limited 2021
Materias:
Acceso en línea:https://doaj.org/article/8a8821df16924998a78ebfc3cb42ddb1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:8a8821df16924998a78ebfc3cb42ddb1
record_format dspace
spelling oai:doaj.org-article:8a8821df16924998a78ebfc3cb42ddb12021-11-08T02:35:29ZAnalysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature1741-428810.1155/2021/5776487https://doaj.org/article/8a8821df16924998a78ebfc3cb42ddb12021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5776487https://doaj.org/toc/1741-4288Objective. To discuss the influence of high-dose recombinant human growth hormone (rhGH) therapy on serum vitamin D and insulin-like growth factor-1 (IGF-1) levels in school-age children with idiopathic short stature (ISS). Method. A total of 103 school-age children with ISS were selected from June 2016 to June 2020 in our hospital. The enrolled cases were divided into the low-dose group (n = 59) and high-dose group (n = 44) according to the treatment dose of rhGH. After the treatment, the height (Ht), height standard deviation score (Ht SDS), growth velocity (GV), and other indicators were recorded. The serum 25-hydroxy vitamin D [25-(OH)D] and IGF-1 levels of the two groups were tested, and the occurrence of adverse reactions was recorded. Results. After treatment, the high-dose group outperformed the low-dose group in various growth effect indicators such as Ht, Ht SDS, and GV (P<0.05). After treatment, the serum 25-(OH)D of children with ISS in the two groups increased significantly, but there was no significant difference between the two groups (P>0.05). After treatment, the serum IGF-1 of children with ISS in the two groups increased significantly, but there was no significant difference between the two groups (P>0.05). For children with ISS, adverse reactions induced by rhGH therapy were very rare. There was no significant difference in the incidence of adverse reactions induced by different doses of rhGH in the treatment of ISS (P>0.05). Conclusion. rhGH has definite efficacy in the treatment of ISS children, for it can significantly increase the annual growth rate of ISS children in a dose-dependent manner. High-dose rhGH for ISS has a better therapeutic effect. At the same time, regardless of the dose level of rhGH, serum 25-(OH)D and IGF-1 levels in children with ISS were increased, with less adverse reactions and higher safety.Juan LiXuehui ZhangShuyong XieShuangshuang FengMin NiuHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Other systems of medicine
RZ201-999
spellingShingle Other systems of medicine
RZ201-999
Juan Li
Xuehui Zhang
Shuyong Xie
Shuangshuang Feng
Min Niu
Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature
description Objective. To discuss the influence of high-dose recombinant human growth hormone (rhGH) therapy on serum vitamin D and insulin-like growth factor-1 (IGF-1) levels in school-age children with idiopathic short stature (ISS). Method. A total of 103 school-age children with ISS were selected from June 2016 to June 2020 in our hospital. The enrolled cases were divided into the low-dose group (n = 59) and high-dose group (n = 44) according to the treatment dose of rhGH. After the treatment, the height (Ht), height standard deviation score (Ht SDS), growth velocity (GV), and other indicators were recorded. The serum 25-hydroxy vitamin D [25-(OH)D] and IGF-1 levels of the two groups were tested, and the occurrence of adverse reactions was recorded. Results. After treatment, the high-dose group outperformed the low-dose group in various growth effect indicators such as Ht, Ht SDS, and GV (P<0.05). After treatment, the serum 25-(OH)D of children with ISS in the two groups increased significantly, but there was no significant difference between the two groups (P>0.05). After treatment, the serum IGF-1 of children with ISS in the two groups increased significantly, but there was no significant difference between the two groups (P>0.05). For children with ISS, adverse reactions induced by rhGH therapy were very rare. There was no significant difference in the incidence of adverse reactions induced by different doses of rhGH in the treatment of ISS (P>0.05). Conclusion. rhGH has definite efficacy in the treatment of ISS children, for it can significantly increase the annual growth rate of ISS children in a dose-dependent manner. High-dose rhGH for ISS has a better therapeutic effect. At the same time, regardless of the dose level of rhGH, serum 25-(OH)D and IGF-1 levels in children with ISS were increased, with less adverse reactions and higher safety.
format article
author Juan Li
Xuehui Zhang
Shuyong Xie
Shuangshuang Feng
Min Niu
author_facet Juan Li
Xuehui Zhang
Shuyong Xie
Shuangshuang Feng
Min Niu
author_sort Juan Li
title Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature
title_short Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature
title_full Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature
title_fullStr Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature
title_full_unstemmed Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature
title_sort analysis of the influence of high-dose rhgh therapy on serum vitamin d and igf-1 levels in school-age children with idiopathic short stature
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/8a8821df16924998a78ebfc3cb42ddb1
work_keys_str_mv AT juanli analysisoftheinfluenceofhighdoserhghtherapyonserumvitamindandigf1levelsinschoolagechildrenwithidiopathicshortstature
AT xuehuizhang analysisoftheinfluenceofhighdoserhghtherapyonserumvitamindandigf1levelsinschoolagechildrenwithidiopathicshortstature
AT shuyongxie analysisoftheinfluenceofhighdoserhghtherapyonserumvitamindandigf1levelsinschoolagechildrenwithidiopathicshortstature
AT shuangshuangfeng analysisoftheinfluenceofhighdoserhghtherapyonserumvitamindandigf1levelsinschoolagechildrenwithidiopathicshortstature
AT minniu analysisoftheinfluenceofhighdoserhghtherapyonserumvitamindandigf1levelsinschoolagechildrenwithidiopathicshortstature
_version_ 1718443204707090432