Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy

Decreased temperatures lengthen C. elegans lifespan by mechanisms that are not fully understood. Here the authors show that autophagy activation contributes to lifespan extension at low temperatures and that this involves adiponectin receptor PAQR-2 signaling.

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Auteurs principaux: Yuan-Li Chen, Jun Tao, Pei-Ji Zhao, Wei Tang, Jian-Ping Xu, Ke-Qin Zhang, Cheng-Gang Zou
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
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Accès en ligne:https://doaj.org/article/8a8c0d5d4e46418e944dff6275a69a07
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