Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Samer Hasan Hussein-Al-Ali,1 Mohamed Ezzat El Zowalaty,2,5 Mohd Zobir Hussein,3 Maznah Ismail,1,4 Dena Dorniani,3 Thomas J Webster6,7 1Laboratory of Molecular Biomedicine, 2Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, 3Materials Synthesis and Characterization Laboratory,...

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Autores principales:	Hussein-Al-Ali SH, El Zowalaty ME, Hussein MZ, Ismail M, Dorniani D, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8a8cb810b23743a0b84610247ab37f0f
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spelling	oai:doaj.org-article:8a8cb810b23743a0b84610247ab37f0f2021-12-02T04:52:23ZNovel kojic acid-polymer-based magnetic nanocomposites for medical applications1178-2013https://doaj.org/article/8a8cb810b23743a0b84610247ab37f0f2014-01-01T00:00:00Zhttp://www.dovepress.com/novel-kojic-acid-polymer-based-magnetic-nanocomposites-for-medical-app-a15438https://doaj.org/toc/1178-2013 Samer Hasan Hussein-Al-Ali,1 Mohamed Ezzat El Zowalaty,2,5 Mohd Zobir Hussein,3 Maznah Ismail,1,4 Dena Dorniani,3 Thomas J Webster6,7 1Laboratory of Molecular Biomedicine, 2Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, 3Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 4Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 5Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; 6Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 7Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Iron oxide magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of iron salts in sodium hydroxide followed by coating separately with chitosan (CS) and polyethylene glycol (PEG) to form CS-MNPs and PEG-MNPs nanoparticles, respectively. They were then loaded with kojic acid (KA), a pharmacologically bioactive natural compound, to form KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The MNPs and their nanocomposites were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. The powder X-ray diffraction data suggest that all formulations consisted of highly crystalline, pure magnetite Fe3O4. The Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the presence of both polymers and KA in the nanocomposites. Magnetization curves showed that both nanocomposites (KA-CS-MNPs and KA-PEG-MNPs) were superparamagnetic with saturation magnetizations of 8.1 emu/g and 26.4 emu/g, respectively. The KA drug loading was estimated using ultraviolet–visible spectroscopy, which gave a loading of 12.2% and 8.3% for the KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The release profile of the KA from the nanocomposites followed a pseudo second-order kinetic model. The agar diffusion test was performed to evaluate the antimicrobial activity for both KA-CS-MNPs and KA-PEG-MNPs nanocomposites against a number of microorganisms using two Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus subtilis) and one Gram-negative (Salmonella enterica) species, and showed some antibacterial activity, which could be enhanced in future studies by optimizing drug loading. This study provided evidence for the promise for the further investigation of the possible beneficial biological activities of KA and both KA-CS-MNPs and KA-PEG-MNPs nanocomposites in nanopharmaceutical applications. Keywords: chitosan, polyethylene glycol, magnetic nanoparticle, kojic acid, controlled release, biological activityHussein-Al-Ali SHEl Zowalaty MEHussein MZIsmail MDorniani DWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 351-362 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hussein-Al-Ali SH El Zowalaty ME Hussein MZ Ismail M Dorniani D Webster TJ Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
description	Samer Hasan Hussein-Al-Ali,1 Mohamed Ezzat El Zowalaty,2,5 Mohd Zobir Hussein,3 Maznah Ismail,1,4 Dena Dorniani,3 Thomas J Webster6,7 1Laboratory of Molecular Biomedicine, 2Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, 3Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 4Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 5Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia; 6Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 7Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Iron oxide magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of iron salts in sodium hydroxide followed by coating separately with chitosan (CS) and polyethylene glycol (PEG) to form CS-MNPs and PEG-MNPs nanoparticles, respectively. They were then loaded with kojic acid (KA), a pharmacologically bioactive natural compound, to form KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The MNPs and their nanocomposites were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. The powder X-ray diffraction data suggest that all formulations consisted of highly crystalline, pure magnetite Fe3O4. The Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the presence of both polymers and KA in the nanocomposites. Magnetization curves showed that both nanocomposites (KA-CS-MNPs and KA-PEG-MNPs) were superparamagnetic with saturation magnetizations of 8.1 emu/g and 26.4 emu/g, respectively. The KA drug loading was estimated using ultraviolet–visible spectroscopy, which gave a loading of 12.2% and 8.3% for the KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The release profile of the KA from the nanocomposites followed a pseudo second-order kinetic model. The agar diffusion test was performed to evaluate the antimicrobial activity for both KA-CS-MNPs and KA-PEG-MNPs nanocomposites against a number of microorganisms using two Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus subtilis) and one Gram-negative (Salmonella enterica) species, and showed some antibacterial activity, which could be enhanced in future studies by optimizing drug loading. This study provided evidence for the promise for the further investigation of the possible beneficial biological activities of KA and both KA-CS-MNPs and KA-PEG-MNPs nanocomposites in nanopharmaceutical applications. Keywords: chitosan, polyethylene glycol, magnetic nanoparticle, kojic acid, controlled release, biological activity
format	article
author	Hussein-Al-Ali SH El Zowalaty ME Hussein MZ Ismail M Dorniani D Webster TJ
author_facet	Hussein-Al-Ali SH El Zowalaty ME Hussein MZ Ismail M Dorniani D Webster TJ
author_sort	Hussein-Al-Ali SH
title	Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
title_short	Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
title_full	Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
title_fullStr	Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
title_full_unstemmed	Novel kojic acid-polymer-based magnetic nanocomposites for medical applications
title_sort	novel kojic acid-polymer-based magnetic nanocomposites for medical applications
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8a8cb810b23743a0b84610247ab37f0f
work_keys_str_mv	AT husseinalalish novelkojicacidpolymerbasedmagneticnanocompositesformedicalapplications AT elzowalatyme novelkojicacidpolymerbasedmagneticnanocompositesformedicalapplications AT husseinmz novelkojicacidpolymerbasedmagneticnanocompositesformedicalapplications AT ismailm novelkojicacidpolymerbasedmagneticnanocompositesformedicalapplications AT dornianid novelkojicacidpolymerbasedmagneticnanocompositesformedicalapplications AT webstertj novelkojicacidpolymerbasedmagneticnanocompositesformedicalapplications
_version_	1718401020629876736

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

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