MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy
How Mycobacterium tuberculosis (Mtb) escapes autophagy-mediated clearance is poorly understood. Here, Liu et al. show that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/8a8d3e4e1ac64edeac9c5ba35b7b60dc |
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oai:doaj.org-article:8a8d3e4e1ac64edeac9c5ba35b7b60dc2021-12-02T16:49:17ZMicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy10.1038/s41467-018-06836-42041-1723https://doaj.org/article/8a8d3e4e1ac64edeac9c5ba35b7b60dc2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06836-4https://doaj.org/toc/2041-1723How Mycobacterium tuberculosis (Mtb) escapes autophagy-mediated clearance is poorly understood. Here, Liu et al. show that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb.Feng LiuJianxia ChenPeng WangHaohao LiYilong ZhouHaipeng LiuZhonghua LiuRuijuan ZhengLin WangHua YangZhenling CuiFei WangXiaochen HuangJie WangWei ShaHeping XiaoBaoxue GeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Feng Liu Jianxia Chen Peng Wang Haohao Li Yilong Zhou Haipeng Liu Zhonghua Liu Ruijuan Zheng Lin Wang Hua Yang Zhenling Cui Fei Wang Xiaochen Huang Jie Wang Wei Sha Heping Xiao Baoxue Ge MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy |
| description |
How Mycobacterium tuberculosis (Mtb) escapes autophagy-mediated clearance is poorly understood. Here, Liu et al. show that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb. |
| format |
article |
| author |
Feng Liu Jianxia Chen Peng Wang Haohao Li Yilong Zhou Haipeng Liu Zhonghua Liu Ruijuan Zheng Lin Wang Hua Yang Zhenling Cui Fei Wang Xiaochen Huang Jie Wang Wei Sha Heping Xiao Baoxue Ge |
| author_facet |
Feng Liu Jianxia Chen Peng Wang Haohao Li Yilong Zhou Haipeng Liu Zhonghua Liu Ruijuan Zheng Lin Wang Hua Yang Zhenling Cui Fei Wang Xiaochen Huang Jie Wang Wei Sha Heping Xiao Baoxue Ge |
| author_sort |
Feng Liu |
| title |
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy |
| title_short |
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy |
| title_full |
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy |
| title_fullStr |
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy |
| title_full_unstemmed |
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy |
| title_sort |
microrna-27a controls the intracellular survival of mycobacterium tuberculosis by regulating calcium-associated autophagy |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/8a8d3e4e1ac64edeac9c5ba35b7b60dc |
| work_keys_str_mv |
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1718383407632744448 |