Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites

Summary: Plant proteins exert effects of reducing cardio-cerebrovascular disease-related mortality partly via cholesterol-lowering, which was associated with gut microbiota. Here, we verify that there are significant differences in cholesterol levels among hamsters consuming different proteins. The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li-Tao Tong, Tianzhen Xiao, Lili Wang, Cong Lu, Liya Liu, Xianrong Zhou, Aixia Wang, Wanyu Qin, Fengzhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological science Endocrinology Microbiology Science Q
Acceso en línea:	https://doaj.org/article/8a91d064e02d48c69620af0c5ee8e92b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a91d064e02d48c69620af0c5ee8e92b
record_format	dspace
spelling	oai:doaj.org-article:8a91d064e02d48c69620af0c5ee8e92b2021-12-04T04:35:31ZPlant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites2589-004210.1016/j.isci.2021.103435https://doaj.org/article/8a91d064e02d48c69620af0c5ee8e92b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014061https://doaj.org/toc/2589-0042Summary: Plant proteins exert effects of reducing cardio-cerebrovascular disease-related mortality partly via cholesterol-lowering, which was associated with gut microbiota. Here, we verify that there are significant differences in cholesterol levels among hamsters consuming different proteins. The decisive roles of gut microbiota in regulating host cholesterol are illustrated by the fact that the difference in serum cholesterol levels between hamsters feeding with pea protein and pork protein disappeared when treated with antibiotics. The results of cross-over intervention of pea and pork protein show that serum cholesterol levels are reversed with dietary exchange. The corresponding changes in microbiota suggest that Muribaculaceae are responsible for the inhibitory effect of pea protein on serum cholesterol level, whereas the opposite effect of pork protein is due to Erysipelotrichaceae. Moreover, pea protein supplement alters cecal metabolites including arginine/histidine pathway, primary bile acid biosynthesis, short-chain fatty acids, and other lipid-like molecules involved in cholesterol metabolism.Li-Tao TongTianzhen XiaoLili WangCong LuLiya LiuXianrong ZhouAixia WangWanyu QinFengzhong WangElsevierarticleBiological scienceEndocrinologyMicrobiologyScienceQENiScience, Vol 24, Iss 12, Pp 103435- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological science Endocrinology Microbiology Science Q
spellingShingle	Biological science Endocrinology Microbiology Science Q Li-Tao Tong Tianzhen Xiao Lili Wang Cong Lu Liya Liu Xianrong Zhou Aixia Wang Wanyu Qin Fengzhong Wang Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
description	Summary: Plant proteins exert effects of reducing cardio-cerebrovascular disease-related mortality partly via cholesterol-lowering, which was associated with gut microbiota. Here, we verify that there are significant differences in cholesterol levels among hamsters consuming different proteins. The decisive roles of gut microbiota in regulating host cholesterol are illustrated by the fact that the difference in serum cholesterol levels between hamsters feeding with pea protein and pork protein disappeared when treated with antibiotics. The results of cross-over intervention of pea and pork protein show that serum cholesterol levels are reversed with dietary exchange. The corresponding changes in microbiota suggest that Muribaculaceae are responsible for the inhibitory effect of pea protein on serum cholesterol level, whereas the opposite effect of pork protein is due to Erysipelotrichaceae. Moreover, pea protein supplement alters cecal metabolites including arginine/histidine pathway, primary bile acid biosynthesis, short-chain fatty acids, and other lipid-like molecules involved in cholesterol metabolism.
format	article
author	Li-Tao Tong Tianzhen Xiao Lili Wang Cong Lu Liya Liu Xianrong Zhou Aixia Wang Wanyu Qin Fengzhong Wang
author_facet	Li-Tao Tong Tianzhen Xiao Lili Wang Cong Lu Liya Liu Xianrong Zhou Aixia Wang Wanyu Qin Fengzhong Wang
author_sort	Li-Tao Tong
title	Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
title_short	Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
title_full	Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
title_fullStr	Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
title_full_unstemmed	Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
title_sort	plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8a91d064e02d48c69620af0c5ee8e92b
work_keys_str_mv	AT litaotong plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT tianzhenxiao plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT liliwang plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT conglu plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT liyaliu plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT xianrongzhou plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT aixiawang plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT wanyuqin plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites AT fengzhongwang plantproteinreducesserumcholesterollevelsinhypercholesterolemiahamstersbymodulatingthecompositionsofgutmicrobiotaandmetabolites
_version_	1718372925592043520

Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites

Ejemplares similares