Adjuvant systemic therapy in older women with breast cancer

Julieta Leone,1 Bernardo Amadeo Leone,1 José Pablo Leone2 1Department of Medical Oncology, Grupo Oncológico Cooperativo del Sur (GOCS), Neuquén, Argentina; 2Department of Internal Medicine, Division of Hematology-Oncology and Blood & Marrow Transplantation, U...

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Autores principales:	Leone J, Leone BA, Leone JP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Breast Cancer Adjuvant Therapy Chemotherapy Endocrine Therapy Elderly. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8a9ad08e60214e8889f202e54ed37e10
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spelling	oai:doaj.org-article:8a9ad08e60214e8889f202e54ed37e102021-12-02T01:09:21ZAdjuvant systemic therapy in older women with breast cancer1179-1314https://doaj.org/article/8a9ad08e60214e8889f202e54ed37e102016-07-01T00:00:00Zhttps://www.dovepress.com/adjuvant-systemic-therapy-in-older-women-with-breast-cancer-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Julieta Leone,1 Bernardo Amadeo Leone,1 José Pablo Leone2 1Department of Medical Oncology, Grupo Oncológico Cooperativo del Sur (GOCS), Neuquén, Argentina; 2Department of Internal Medicine, Division of Hematology-Oncology and Blood & Marrow Transplantation, University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA Abstract: Breast cancer in the elderly is an increasing clinical problem. In addition, ~60% of deaths from breast cancer occur in women aged 65 years and older. Despite this, older women with breast cancer have been underrepresented in clinical trials, and this has led to less than optimal evidence to guide their therapy. The management of elderly women with early breast cancer is a complex process that requires careful evaluation of life expectancy, comorbidities, patient values, and risks and benefits of available treatment options. This review will focus on current adjuvant systemic therapy options for older women with breast cancer, discuss the principles in the decision-making process, and define the role of endocrine therapy, chemotherapy, and targeted agents. Keywords: breast cancer, adjuvant therapy, chemotherapy, endocrine therapy, elderlyLeone JLeone BALeone JPDove Medical PressarticleBreast CancerAdjuvant TherapyChemotherapyEndocrine TherapyElderly.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 141-147 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast Cancer Adjuvant Therapy Chemotherapy Endocrine Therapy Elderly. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Breast Cancer Adjuvant Therapy Chemotherapy Endocrine Therapy Elderly. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Leone J Leone BA Leone JP Adjuvant systemic therapy in older women with breast cancer
description	Julieta Leone,1 Bernardo Amadeo Leone,1 José Pablo Leone2 1Department of Medical Oncology, Grupo Oncológico Cooperativo del Sur (GOCS), Neuquén, Argentina; 2Department of Internal Medicine, Division of Hematology-Oncology and Blood & Marrow Transplantation, University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA Abstract: Breast cancer in the elderly is an increasing clinical problem. In addition, ~60% of deaths from breast cancer occur in women aged 65 years and older. Despite this, older women with breast cancer have been underrepresented in clinical trials, and this has led to less than optimal evidence to guide their therapy. The management of elderly women with early breast cancer is a complex process that requires careful evaluation of life expectancy, comorbidities, patient values, and risks and benefits of available treatment options. This review will focus on current adjuvant systemic therapy options for older women with breast cancer, discuss the principles in the decision-making process, and define the role of endocrine therapy, chemotherapy, and targeted agents. Keywords: breast cancer, adjuvant therapy, chemotherapy, endocrine therapy, elderly
format	article
author	Leone J Leone BA Leone JP
author_facet	Leone J Leone BA Leone JP
author_sort	Leone J
title	Adjuvant systemic therapy in older women with breast cancer
title_short	Adjuvant systemic therapy in older women with breast cancer
title_full	Adjuvant systemic therapy in older women with breast cancer
title_fullStr	Adjuvant systemic therapy in older women with breast cancer
title_full_unstemmed	Adjuvant systemic therapy in older women with breast cancer
title_sort	adjuvant systemic therapy in older women with breast cancer
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8a9ad08e60214e8889f202e54ed37e10
work_keys_str_mv	AT leonej adjuvantsystemictherapyinolderwomenwithbreastcancer AT leoneba adjuvantsystemictherapyinolderwomenwithbreastcancer AT leonejp adjuvantsystemictherapyinolderwomenwithbreastcancer
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Adjuvant systemic therapy in older women with breast cancer

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