Oxidative Transformations of 3,4-Dihydroxyphenylacetaldehyde Generate Potential Reactive Intermediates as Causative Agents for Its Neurotoxicity

Neurogenerative diseases, such as Parkinson’s disease, are associated, not only with the selective loss of dopamine (DA), but also with the accumulation of reactive catechol-aldehyde, 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is formed as the immediate oxidation product of cytoplasmic DA by mon...

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Autores principales:	Shosuke Ito, Hitomi Tanaka, Makoto Ojika, Kazumasa Wakamatsu, Manickam Sugumaran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3,4-dihydroxyphenylacetaldehyde (DOPAL) 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) Parkinson’s disease tyrosinase <i>ortho</i>-quinone quinone methide Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8a9b51fe520c49f8aa93f5c648023294
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Oxidative Transformations of 3,4-Dihydroxyphenylacetaldehyde Generate Potential Reactive Intermediates as Causative Agents for Its Neurotoxicity

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