Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects

One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as “developmental origins of health and disease” (DOHaD), can have its origins in early life. Offspring MetS can be programmed by various adverse early-life c...

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Autores principales:	Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, You-Lin Tain
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular disease obesity hypertension oxidative stress metabolic syndrome dyslipidemia Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8a9d63a9a7834faa9b44cdbf2dac93c9
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id	oai:doaj.org-article:8a9d63a9a7834faa9b44cdbf2dac93c9
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spelling	oai:doaj.org-article:8a9d63a9a7834faa9b44cdbf2dac93c92021-11-11T17:17:41ZEarly-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects10.3390/ijms2221118721422-00671661-6596https://doaj.org/article/8a9d63a9a7834faa9b44cdbf2dac93c92021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11872https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as “developmental origins of health and disease” (DOHaD), can have its origins in early life. Offspring MetS can be programmed by various adverse early-life conditions, such as nutrition imbalance, maternal conditions or diseases, maternal chemical exposure, and medication use. Conversely, early interventions have shown potential to revoke programming processes to prevent MetS of developmental origins, namely reprogramming. In this review, we summarize what is currently known about adverse environmental insults implicated in MetS of developmental origins, including the fundamental underlying mechanisms. We also describe animal models that have been developed to study the developmental programming of MetS. This review extends previous research reviews by addressing implementation of reprogramming strategies to prevent the programming of MetS. These mechanism-targeted strategies include antioxidants, melatonin, resveratrol, probiotics/prebiotics, and amino acids. Much work remains to be accomplished to determine the insults that could induce MetS, to identify the mechanisms behind MetS programming, and to develop potential reprogramming strategies for clinical translation.Chien-Ning HsuChih-Yao HouWei-Hsuan HsuYou-Lin TainMDPI AGarticlecardiovascular diseaseobesityhypertensionoxidative stressmetabolic syndromedyslipidemiaBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11872, p 11872 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease obesity hypertension oxidative stress metabolic syndrome dyslipidemia Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cardiovascular disease obesity hypertension oxidative stress metabolic syndrome dyslipidemia Biology (General) QH301-705.5 Chemistry QD1-999 Chien-Ning Hsu Chih-Yao Hou Wei-Hsuan Hsu You-Lin Tain Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
description	One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as “developmental origins of health and disease” (DOHaD), can have its origins in early life. Offspring MetS can be programmed by various adverse early-life conditions, such as nutrition imbalance, maternal conditions or diseases, maternal chemical exposure, and medication use. Conversely, early interventions have shown potential to revoke programming processes to prevent MetS of developmental origins, namely reprogramming. In this review, we summarize what is currently known about adverse environmental insults implicated in MetS of developmental origins, including the fundamental underlying mechanisms. We also describe animal models that have been developed to study the developmental programming of MetS. This review extends previous research reviews by addressing implementation of reprogramming strategies to prevent the programming of MetS. These mechanism-targeted strategies include antioxidants, melatonin, resveratrol, probiotics/prebiotics, and amino acids. Much work remains to be accomplished to determine the insults that could induce MetS, to identify the mechanisms behind MetS programming, and to develop potential reprogramming strategies for clinical translation.
format	article
author	Chien-Ning Hsu Chih-Yao Hou Wei-Hsuan Hsu You-Lin Tain
author_facet	Chien-Ning Hsu Chih-Yao Hou Wei-Hsuan Hsu You-Lin Tain
author_sort	Chien-Ning Hsu
title	Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
title_short	Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
title_full	Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
title_fullStr	Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
title_full_unstemmed	Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects
title_sort	early-life origins of metabolic syndrome: mechanisms and preventive aspects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8a9d63a9a7834faa9b44cdbf2dac93c9
work_keys_str_mv	AT chienninghsu earlylifeoriginsofmetabolicsyndromemechanismsandpreventiveaspects AT chihyaohou earlylifeoriginsofmetabolicsyndromemechanismsandpreventiveaspects AT weihsuanhsu earlylifeoriginsofmetabolicsyndromemechanismsandpreventiveaspects AT youlintain earlylifeoriginsofmetabolicsyndromemechanismsandpreventiveaspects
_version_	1718432129993408512

Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects

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