Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
<h4>Objective</h4> Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. <h4>Methods</h4> A cohort of adults receiving primary care withi...
Guardado en:
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/8a9de67be533421e9317596931736974 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:8a9de67be533421e9317596931736974 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:8a9de67be533421e93175969317369742021-11-11T07:14:46ZEffects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization1932-6203https://doaj.org/article/8a9de67be533421e93175969317369742021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565747/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. <h4>Methods</h4> A cohort of adults receiving primary care within Geisinger Health System between 2001–2017 was retrospectively studied. Patients with ≥3 weight measurements in the two-year index period and obesity at baseline (BMI ≥30 kg/m2) were categorized: Obesity Maintainers (reference group) maintained weight within +/-3%; Weight Loss Rebounders lost ≥5% body weight in year one, regaining ≥20% of weight loss in year two; Weight Loss Maintainers lost ≥5% body weight in year one, maintaining ≥80% of weight loss. Association with development of osteoarthritis, cancer, opioid use, and depression/anxiety, was assessed; healthcare resource utilization was quantified. Magnitude of weight loss among maintainers was evaluated for impact on health outcomes. <h4>Results</h4> In total, 63,567 patients were analyzed including 67% Obesity Maintainers, 19% Weight Loss Rebounders, and 14% Weight Loss Maintainers; median follow-up was 9.7 years. Time until osteoarthritis onset was delayed for Weight Loss Maintainers compared to Obesity Maintainers (Logrank test p <0.0001). Female Weight Loss Maintainers had a 19% and 24% lower risk of developing any cancer (p = 0.0022) or obesity-related cancer (p = 0.0021), respectively. No significant trends were observed for opioid use. Weight loss Rebounders and Maintainers had increased risk (14% and 25%) of future treatment for anxiety/depression (both <0.0001). Weight loss maintenance of >15% weight loss was associated with the greatest decrease in incident osteoarthritis. Healthcare resource utilization was significantly higher for Weight Loss Rebounders and Maintainers compared to Obesity Maintainers. Increased weight loss among Weight Loss Maintainers trended with lower overall healthcare resource utilization, except for hospitalizations. <h4>Conclusions</h4> In people with obesity, sustained weight loss was associated with greater clinical benefits than regained short-term weight loss and obesity maintenance. Higher weight loss magnitudes were associated with delayed onset of osteoarthritis and led to decreased healthcare utilization.G. Craig WoodLisa Bailey-DavisPeter BenottiAdam CookJames DoveJacob MoweryAbhilasha RamasamyNeeraj IyerB. Gabriel SmolarzNeela KumarChristopher D. StillPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q G. Craig Wood Lisa Bailey-Davis Peter Benotti Adam Cook James Dove Jacob Mowery Abhilasha Ramasamy Neeraj Iyer B. Gabriel Smolarz Neela Kumar Christopher D. Still Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
description |
<h4>Objective</h4> Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. <h4>Methods</h4> A cohort of adults receiving primary care within Geisinger Health System between 2001–2017 was retrospectively studied. Patients with ≥3 weight measurements in the two-year index period and obesity at baseline (BMI ≥30 kg/m2) were categorized: Obesity Maintainers (reference group) maintained weight within +/-3%; Weight Loss Rebounders lost ≥5% body weight in year one, regaining ≥20% of weight loss in year two; Weight Loss Maintainers lost ≥5% body weight in year one, maintaining ≥80% of weight loss. Association with development of osteoarthritis, cancer, opioid use, and depression/anxiety, was assessed; healthcare resource utilization was quantified. Magnitude of weight loss among maintainers was evaluated for impact on health outcomes. <h4>Results</h4> In total, 63,567 patients were analyzed including 67% Obesity Maintainers, 19% Weight Loss Rebounders, and 14% Weight Loss Maintainers; median follow-up was 9.7 years. Time until osteoarthritis onset was delayed for Weight Loss Maintainers compared to Obesity Maintainers (Logrank test p <0.0001). Female Weight Loss Maintainers had a 19% and 24% lower risk of developing any cancer (p = 0.0022) or obesity-related cancer (p = 0.0021), respectively. No significant trends were observed for opioid use. Weight loss Rebounders and Maintainers had increased risk (14% and 25%) of future treatment for anxiety/depression (both <0.0001). Weight loss maintenance of >15% weight loss was associated with the greatest decrease in incident osteoarthritis. Healthcare resource utilization was significantly higher for Weight Loss Rebounders and Maintainers compared to Obesity Maintainers. Increased weight loss among Weight Loss Maintainers trended with lower overall healthcare resource utilization, except for hospitalizations. <h4>Conclusions</h4> In people with obesity, sustained weight loss was associated with greater clinical benefits than regained short-term weight loss and obesity maintenance. Higher weight loss magnitudes were associated with delayed onset of osteoarthritis and led to decreased healthcare utilization. |
format |
article |
author |
G. Craig Wood Lisa Bailey-Davis Peter Benotti Adam Cook James Dove Jacob Mowery Abhilasha Ramasamy Neeraj Iyer B. Gabriel Smolarz Neela Kumar Christopher D. Still |
author_facet |
G. Craig Wood Lisa Bailey-Davis Peter Benotti Adam Cook James Dove Jacob Mowery Abhilasha Ramasamy Neeraj Iyer B. Gabriel Smolarz Neela Kumar Christopher D. Still |
author_sort |
G. Craig Wood |
title |
Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
title_short |
Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
title_full |
Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
title_fullStr |
Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
title_full_unstemmed |
Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
title_sort |
effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doaj.org/article/8a9de67be533421e9317596931736974 |
work_keys_str_mv |
AT gcraigwood effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT lisabaileydavis effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT peterbenotti effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT adamcook effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT jamesdove effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT jacobmowery effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT abhilasharamasamy effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT neerajiyer effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT bgabrielsmolarz effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT neelakumar effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization AT christopherdstill effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization |
_version_ |
1718439417645891584 |