Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization

<h4>Objective</h4> Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. <h4>Methods</h4> A cohort of adults receiving primary care withi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: G. Craig Wood, Lisa Bailey-Davis, Peter Benotti, Adam Cook, James Dove, Jacob Mowery, Abhilasha Ramasamy, Neeraj Iyer, B. Gabriel Smolarz, Neela Kumar, Christopher D. Still
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/8a9de67be533421e9317596931736974
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:8a9de67be533421e9317596931736974
record_format dspace
spelling oai:doaj.org-article:8a9de67be533421e93175969317369742021-11-11T07:14:46ZEffects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization1932-6203https://doaj.org/article/8a9de67be533421e93175969317369742021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565747/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. <h4>Methods</h4> A cohort of adults receiving primary care within Geisinger Health System between 2001–2017 was retrospectively studied. Patients with ≥3 weight measurements in the two-year index period and obesity at baseline (BMI ≥30 kg/m2) were categorized: Obesity Maintainers (reference group) maintained weight within +/-3%; Weight Loss Rebounders lost ≥5% body weight in year one, regaining ≥20% of weight loss in year two; Weight Loss Maintainers lost ≥5% body weight in year one, maintaining ≥80% of weight loss. Association with development of osteoarthritis, cancer, opioid use, and depression/anxiety, was assessed; healthcare resource utilization was quantified. Magnitude of weight loss among maintainers was evaluated for impact on health outcomes. <h4>Results</h4> In total, 63,567 patients were analyzed including 67% Obesity Maintainers, 19% Weight Loss Rebounders, and 14% Weight Loss Maintainers; median follow-up was 9.7 years. Time until osteoarthritis onset was delayed for Weight Loss Maintainers compared to Obesity Maintainers (Logrank test p <0.0001). Female Weight Loss Maintainers had a 19% and 24% lower risk of developing any cancer (p = 0.0022) or obesity-related cancer (p = 0.0021), respectively. No significant trends were observed for opioid use. Weight loss Rebounders and Maintainers had increased risk (14% and 25%) of future treatment for anxiety/depression (both <0.0001). Weight loss maintenance of >15% weight loss was associated with the greatest decrease in incident osteoarthritis. Healthcare resource utilization was significantly higher for Weight Loss Rebounders and Maintainers compared to Obesity Maintainers. Increased weight loss among Weight Loss Maintainers trended with lower overall healthcare resource utilization, except for hospitalizations. <h4>Conclusions</h4> In people with obesity, sustained weight loss was associated with greater clinical benefits than regained short-term weight loss and obesity maintenance. Higher weight loss magnitudes were associated with delayed onset of osteoarthritis and led to decreased healthcare utilization.G. Craig WoodLisa Bailey-DavisPeter BenottiAdam CookJames DoveJacob MoweryAbhilasha RamasamyNeeraj IyerB. Gabriel SmolarzNeela KumarChristopher D. StillPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
G. Craig Wood
Lisa Bailey-Davis
Peter Benotti
Adam Cook
James Dove
Jacob Mowery
Abhilasha Ramasamy
Neeraj Iyer
B. Gabriel Smolarz
Neela Kumar
Christopher D. Still
Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
description <h4>Objective</h4> Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. <h4>Methods</h4> A cohort of adults receiving primary care within Geisinger Health System between 2001–2017 was retrospectively studied. Patients with ≥3 weight measurements in the two-year index period and obesity at baseline (BMI ≥30 kg/m2) were categorized: Obesity Maintainers (reference group) maintained weight within +/-3%; Weight Loss Rebounders lost ≥5% body weight in year one, regaining ≥20% of weight loss in year two; Weight Loss Maintainers lost ≥5% body weight in year one, maintaining ≥80% of weight loss. Association with development of osteoarthritis, cancer, opioid use, and depression/anxiety, was assessed; healthcare resource utilization was quantified. Magnitude of weight loss among maintainers was evaluated for impact on health outcomes. <h4>Results</h4> In total, 63,567 patients were analyzed including 67% Obesity Maintainers, 19% Weight Loss Rebounders, and 14% Weight Loss Maintainers; median follow-up was 9.7 years. Time until osteoarthritis onset was delayed for Weight Loss Maintainers compared to Obesity Maintainers (Logrank test p <0.0001). Female Weight Loss Maintainers had a 19% and 24% lower risk of developing any cancer (p = 0.0022) or obesity-related cancer (p = 0.0021), respectively. No significant trends were observed for opioid use. Weight loss Rebounders and Maintainers had increased risk (14% and 25%) of future treatment for anxiety/depression (both <0.0001). Weight loss maintenance of >15% weight loss was associated with the greatest decrease in incident osteoarthritis. Healthcare resource utilization was significantly higher for Weight Loss Rebounders and Maintainers compared to Obesity Maintainers. Increased weight loss among Weight Loss Maintainers trended with lower overall healthcare resource utilization, except for hospitalizations. <h4>Conclusions</h4> In people with obesity, sustained weight loss was associated with greater clinical benefits than regained short-term weight loss and obesity maintenance. Higher weight loss magnitudes were associated with delayed onset of osteoarthritis and led to decreased healthcare utilization.
format article
author G. Craig Wood
Lisa Bailey-Davis
Peter Benotti
Adam Cook
James Dove
Jacob Mowery
Abhilasha Ramasamy
Neeraj Iyer
B. Gabriel Smolarz
Neela Kumar
Christopher D. Still
author_facet G. Craig Wood
Lisa Bailey-Davis
Peter Benotti
Adam Cook
James Dove
Jacob Mowery
Abhilasha Ramasamy
Neeraj Iyer
B. Gabriel Smolarz
Neela Kumar
Christopher D. Still
author_sort G. Craig Wood
title Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
title_short Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
title_full Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
title_fullStr Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
title_full_unstemmed Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
title_sort effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/8a9de67be533421e9317596931736974
work_keys_str_mv AT gcraigwood effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT lisabaileydavis effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT peterbenotti effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT adamcook effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT jamesdove effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT jacobmowery effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT abhilasharamasamy effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT neerajiyer effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT bgabrielsmolarz effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT neelakumar effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
AT christopherdstill effectsofsustainedweightlossonoutcomesassociatedwithobesitycomorbiditiesandhealthcareresourceutilization
_version_ 1718439417645891584