INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION

Abstract. In the present study, blood levels of circulating immune complexes and of their pathogenic subpopulations were determined in rats following ionizing irradiation. Experimental animals were treated with synthetic Schiff base aromatic amino acid derivatives, nicotinyl-L-tyrosinate or nicotiny...

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Autores principales:	A. S. Boyajyan, S. A. Bajinyan, M. H. Malakyan, L. A. Manukyan, E. A. Arakelova, D. E. Yeghiazaryan
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune complexes ionizing irradiation nicotinyl-l-tyrosinate nicotinyl-l-tryptophanate Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8a9f0ef36fff4fc3b6406c2de8c93e17
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spelling	oai:doaj.org-article:8a9f0ef36fff4fc3b6406c2de8c93e172021-11-18T08:03:40ZINFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION1563-06252313-741X10.15789/1563-0625-2009-2-3-265-268https://doaj.org/article/8a9f0ef36fff4fc3b6406c2de8c93e172014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/317https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In the present study, blood levels of circulating immune complexes and of their pathogenic subpopulations were determined in rats following ionizing irradiation. Experimental animals were treated with synthetic Schiff base aromatic amino acid derivatives, nicotinyl-L-tyrosinate or nicotinyl-L-tryptophanate, before irradiation, whereas untreated irradiated rats served as controls. The results obtained demonstrate significantly increased levels of immune complexes, as well as presence of a pathogenic subpopulation of circulating immune complexes in blood of irradiated animals. In addition, the data obtained suggest a normalizing effect of nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate upon the mentioned parameters. On the basis of these observations, a cyto- and immunoprotective ability of nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate may be proposed.A. S. BoyajyanS. A. BajinyanM. H. MalakyanL. A. ManukyanE. A. ArakelovaD. E. YeghiazaryanSPb RAACIarticleimmune complexesionizing irradiationnicotinyl-l-tyrosinatenicotinyl-l-tryptophanateImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 265-268 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune complexes ionizing irradiation nicotinyl-l-tyrosinate nicotinyl-l-tryptophanate Immunologic diseases. Allergy RC581-607
spellingShingle	immune complexes ionizing irradiation nicotinyl-l-tyrosinate nicotinyl-l-tryptophanate Immunologic diseases. Allergy RC581-607 A. S. Boyajyan S. A. Bajinyan M. H. Malakyan L. A. Manukyan E. A. Arakelova D. E. Yeghiazaryan INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION
description	Abstract. In the present study, blood levels of circulating immune complexes and of their pathogenic subpopulations were determined in rats following ionizing irradiation. Experimental animals were treated with synthetic Schiff base aromatic amino acid derivatives, nicotinyl-L-tyrosinate or nicotinyl-L-tryptophanate, before irradiation, whereas untreated irradiated rats served as controls. The results obtained demonstrate significantly increased levels of immune complexes, as well as presence of a pathogenic subpopulation of circulating immune complexes in blood of irradiated animals. In addition, the data obtained suggest a normalizing effect of nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate upon the mentioned parameters. On the basis of these observations, a cyto- and immunoprotective ability of nicotinyl-L-tyrosinate and nicotinyl-L-tryptophanate may be proposed.
format	article
author	A. S. Boyajyan S. A. Bajinyan M. H. Malakyan L. A. Manukyan E. A. Arakelova D. E. Yeghiazaryan
author_facet	A. S. Boyajyan S. A. Bajinyan M. H. Malakyan L. A. Manukyan E. A. Arakelova D. E. Yeghiazaryan
author_sort	A. S. Boyajyan
title	INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION
title_short	INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION
title_full	INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION
title_fullStr	INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION
title_full_unstemmed	INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION
title_sort	influence of aromatic amino acid derivatives on the levels of immune complexes under ionized radiation
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8a9f0ef36fff4fc3b6406c2de8c93e17
work_keys_str_mv	AT asboyajyan influenceofaromaticaminoacidderivativesonthelevelsofimmunecomplexesunderionizedradiation AT sabajinyan influenceofaromaticaminoacidderivativesonthelevelsofimmunecomplexesunderionizedradiation AT mhmalakyan influenceofaromaticaminoacidderivativesonthelevelsofimmunecomplexesunderionizedradiation AT lamanukyan influenceofaromaticaminoacidderivativesonthelevelsofimmunecomplexesunderionizedradiation AT eaarakelova influenceofaromaticaminoacidderivativesonthelevelsofimmunecomplexesunderionizedradiation AT deyeghiazaryan influenceofaromaticaminoacidderivativesonthelevelsofimmunecomplexesunderionizedradiation
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INFLUENCE OF AROMATIC AMINO ACID DERIVATIVES ON THE LEVELS OF IMMUNE COMPLEXES UNDER IONIZED RADIATION

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