A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage

Thioredoxin reductase (TrxR) plays a crucial part in regulating cellular redox homeostasis. Here, the authors developed a fluorescent probe composed of a five-membered disulphide, a coumarin fluorophore and a urea linker that detects TrxR activity with fast response and high selectivity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Xinming Li, Baoxin Zhang, Chaoxian Yan, Jin Li, Song Wang, Xiangxu Wei, Xiaoyan Jiang, Panpan Zhou, Jianguo Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8aa142024cd44ac3b09061210c99242a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8aa142024cd44ac3b09061210c99242a
record_format	dspace
spelling	oai:doaj.org-article:8aa142024cd44ac3b09061210c99242a2021-12-02T15:35:34ZA fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage10.1038/s41467-019-10807-82041-1723https://doaj.org/article/8aa142024cd44ac3b09061210c99242a2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10807-8https://doaj.org/toc/2041-1723Thioredoxin reductase (TrxR) plays a crucial part in regulating cellular redox homeostasis. Here, the authors developed a fluorescent probe composed of a five-membered disulphide, a coumarin fluorophore and a urea linker that detects TrxR activity with fast response and high selectivity.Xinming LiBaoxin ZhangChaoxian YanJin LiSong WangXiangxu WeiXiaoyan JiangPanpan ZhouJianguo FangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinming Li Baoxin Zhang Chaoxian Yan Jin Li Song Wang Xiangxu Wei Xiaoyan Jiang Panpan Zhou Jianguo Fang A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
description	Thioredoxin reductase (TrxR) plays a crucial part in regulating cellular redox homeostasis. Here, the authors developed a fluorescent probe composed of a five-membered disulphide, a coumarin fluorophore and a urea linker that detects TrxR activity with fast response and high selectivity.
format	article
author	Xinming Li Baoxin Zhang Chaoxian Yan Jin Li Song Wang Xiangxu Wei Xiaoyan Jiang Panpan Zhou Jianguo Fang
author_facet	Xinming Li Baoxin Zhang Chaoxian Yan Jin Li Song Wang Xiangxu Wei Xiaoyan Jiang Panpan Zhou Jianguo Fang
author_sort	Xinming Li
title	A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
title_short	A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
title_full	A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
title_fullStr	A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
title_full_unstemmed	A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
title_sort	fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8aa142024cd44ac3b09061210c99242a
work_keys_str_mv	AT xinmingli afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT baoxinzhang afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT chaoxianyan afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT jinli afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT songwang afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT xiangxuwei afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT xiaoyanjiang afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT panpanzhou afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT jianguofang afastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT xinmingli fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT baoxinzhang fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT chaoxianyan fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT jinli fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT songwang fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT xiangxuwei fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT xiaoyanjiang fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT panpanzhou fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage AT jianguofang fastandspecificfluorescentprobeforthioredoxinreductasethatworksviadisulphidebondcleavage
_version_	1718386545985060864

A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage

Ejemplares similares