Suppression of autophagic activity by Rubicon is a signature of aging
Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models.
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Nature Portfolio
2019
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oai:doaj.org-article:8aa18fda9b7a4cc7bd3ad05d003b9c172021-12-02T17:31:36ZSuppression of autophagic activity by Rubicon is a signature of aging10.1038/s41467-019-08729-62041-1723https://doaj.org/article/8aa18fda9b7a4cc7bd3ad05d003b9c172019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08729-6https://doaj.org/toc/2041-1723Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models.Shuhei NakamuraMasaki ObaMari SuzukiAtsushi TakahashiTadashi YamamuroMari FujiwaraKensuke IkenakaSatoshi MinamiNamine TabataKenichi YamamotoSayaka KuboAyaka TokumuraKanako AkamatsuYumi MiyazakiTsuyoshi KawabataMaho HamasakiKoji FukuiKazunori SangoYoshihisa WatanabeYoshitsugu TakabatakeTomoya S. KitajimaYukinori OkadaHideki MochizukiYoshitaka IsakaAdam AntebiTamotsu YoshimoriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shuhei Nakamura Masaki Oba Mari Suzuki Atsushi Takahashi Tadashi Yamamuro Mari Fujiwara Kensuke Ikenaka Satoshi Minami Namine Tabata Kenichi Yamamoto Sayaka Kubo Ayaka Tokumura Kanako Akamatsu Yumi Miyazaki Tsuyoshi Kawabata Maho Hamasaki Koji Fukui Kazunori Sango Yoshihisa Watanabe Yoshitsugu Takabatake Tomoya S. Kitajima Yukinori Okada Hideki Mochizuki Yoshitaka Isaka Adam Antebi Tamotsu Yoshimori Suppression of autophagic activity by Rubicon is a signature of aging |
| description |
Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models. |
| format |
article |
| author |
Shuhei Nakamura Masaki Oba Mari Suzuki Atsushi Takahashi Tadashi Yamamuro Mari Fujiwara Kensuke Ikenaka Satoshi Minami Namine Tabata Kenichi Yamamoto Sayaka Kubo Ayaka Tokumura Kanako Akamatsu Yumi Miyazaki Tsuyoshi Kawabata Maho Hamasaki Koji Fukui Kazunori Sango Yoshihisa Watanabe Yoshitsugu Takabatake Tomoya S. Kitajima Yukinori Okada Hideki Mochizuki Yoshitaka Isaka Adam Antebi Tamotsu Yoshimori |
| author_facet |
Shuhei Nakamura Masaki Oba Mari Suzuki Atsushi Takahashi Tadashi Yamamuro Mari Fujiwara Kensuke Ikenaka Satoshi Minami Namine Tabata Kenichi Yamamoto Sayaka Kubo Ayaka Tokumura Kanako Akamatsu Yumi Miyazaki Tsuyoshi Kawabata Maho Hamasaki Koji Fukui Kazunori Sango Yoshihisa Watanabe Yoshitsugu Takabatake Tomoya S. Kitajima Yukinori Okada Hideki Mochizuki Yoshitaka Isaka Adam Antebi Tamotsu Yoshimori |
| author_sort |
Shuhei Nakamura |
| title |
Suppression of autophagic activity by Rubicon is a signature of aging |
| title_short |
Suppression of autophagic activity by Rubicon is a signature of aging |
| title_full |
Suppression of autophagic activity by Rubicon is a signature of aging |
| title_fullStr |
Suppression of autophagic activity by Rubicon is a signature of aging |
| title_full_unstemmed |
Suppression of autophagic activity by Rubicon is a signature of aging |
| title_sort |
suppression of autophagic activity by rubicon is a signature of aging |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/8aa18fda9b7a4cc7bd3ad05d003b9c17 |
| work_keys_str_mv |
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| _version_ |
1718380566482518016 |