Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders

Abstract While previous research has investigated neuroradiological findings in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), the entire range of neurodevelopmental disorders (NDDs) has not yet been well-studied using magnetic resonance imaging (MRI). Considerin...

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Autores principales:	Lynnea Myers, Mai-Lan Ho, Elodie Cauvet, Karl Lundin, Torkel Carlsson, Ralf Kuja-Halkola, Kristiina Tammimies, Sven Bölte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8aa4f88a3d3d4b77a05e5abb197f78f6
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spelling	oai:doaj.org-article:8aa4f88a3d3d4b77a05e5abb197f78f62021-12-02T13:46:46ZActionable and incidental neuroradiological findings in twins with neurodevelopmental disorders10.1038/s41598-020-79959-82045-2322https://doaj.org/article/8aa4f88a3d3d4b77a05e5abb197f78f62020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79959-8https://doaj.org/toc/2045-2322Abstract While previous research has investigated neuroradiological findings in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), the entire range of neurodevelopmental disorders (NDDs) has not yet been well-studied using magnetic resonance imaging (MRI). Considering the overlap among NDDs and simultaneous development of the brain and face, guided by molecular signaling, we examined the relationship of actionable and incidental (non-actionable) MRI findings and NDD diagnoses together with facial morphological variants and genetic copy number variants (CNVs). A cross-sectional study was conducted with a twin cohort 8–36 years of age (57% monozygotic, 40% dizygotic), including 372 subjects (46% with NDDs; 47% female) imaged by MRI, 280 with data for facial morphological variants, and 183 for CNVs. Fifty-one percent of participants had MRI findings. Males had a statistically significantly higher percentage of MRI findings (57.7%) compared with females (43.8%, p = 0.03). Twin zygosity was not statistically significantly correlated with incidence or severity of specific MRI findings. No statistically significant association was found between MRI findings and any NDD diagnosis or facial morphological variants; however, MRI findings were statistically significantly associated with the number of CNVs (OR 1.20, 95% CI 1.00–1.44, p = 0.05, adjusted OR for sex 1.24, 95% CI 1.03–1.50, p = 0.02). When combining the presence of MRI findings, facial morphological variants, and CNVs, statistically significant relationships were found with ASD and ADHD diagnoses (p = 0.0006 and p = 0.002, respectively). The results of this study demonstrate that the ability to identify NDDs from combined radiology, morphology, and CNV assessments may be possible. Additionally, twins do not appear to be at increased risk for neuroradiological variants.Lynnea MyersMai-Lan HoElodie CauvetKarl LundinTorkel CarlssonRalf Kuja-HalkolaKristiina TammimiesSven BölteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lynnea Myers Mai-Lan Ho Elodie Cauvet Karl Lundin Torkel Carlsson Ralf Kuja-Halkola Kristiina Tammimies Sven Bölte Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
description	Abstract While previous research has investigated neuroradiological findings in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), the entire range of neurodevelopmental disorders (NDDs) has not yet been well-studied using magnetic resonance imaging (MRI). Considering the overlap among NDDs and simultaneous development of the brain and face, guided by molecular signaling, we examined the relationship of actionable and incidental (non-actionable) MRI findings and NDD diagnoses together with facial morphological variants and genetic copy number variants (CNVs). A cross-sectional study was conducted with a twin cohort 8–36 years of age (57% monozygotic, 40% dizygotic), including 372 subjects (46% with NDDs; 47% female) imaged by MRI, 280 with data for facial morphological variants, and 183 for CNVs. Fifty-one percent of participants had MRI findings. Males had a statistically significantly higher percentage of MRI findings (57.7%) compared with females (43.8%, p = 0.03). Twin zygosity was not statistically significantly correlated with incidence or severity of specific MRI findings. No statistically significant association was found between MRI findings and any NDD diagnosis or facial morphological variants; however, MRI findings were statistically significantly associated with the number of CNVs (OR 1.20, 95% CI 1.00–1.44, p = 0.05, adjusted OR for sex 1.24, 95% CI 1.03–1.50, p = 0.02). When combining the presence of MRI findings, facial morphological variants, and CNVs, statistically significant relationships were found with ASD and ADHD diagnoses (p = 0.0006 and p = 0.002, respectively). The results of this study demonstrate that the ability to identify NDDs from combined radiology, morphology, and CNV assessments may be possible. Additionally, twins do not appear to be at increased risk for neuroradiological variants.
format	article
author	Lynnea Myers Mai-Lan Ho Elodie Cauvet Karl Lundin Torkel Carlsson Ralf Kuja-Halkola Kristiina Tammimies Sven Bölte
author_facet	Lynnea Myers Mai-Lan Ho Elodie Cauvet Karl Lundin Torkel Carlsson Ralf Kuja-Halkola Kristiina Tammimies Sven Bölte
author_sort	Lynnea Myers
title	Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
title_short	Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
title_full	Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
title_fullStr	Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
title_full_unstemmed	Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
title_sort	actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8aa4f88a3d3d4b77a05e5abb197f78f6
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Actionable and incidental neuroradiological findings in twins with neurodevelopmental disorders

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