Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism

Abstract Animals have evolved to maintain homeostasis in a changing external environment by adapting their internal metabolism and feeding behaviour. Metabolism and behaviour are coordinated by neuromodulation; a number of the implicated neuromodulatory systems are homologous between mammals and the...

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Autores principales:	Anders Eriksson, Marlena Raczkowska, Rapeechai Navawongse, Deepak Choudhury, James C. Stewart, Yi Ling Tang, Zhiping Wang, Adam Claridge-Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8aa6e4727d4c43fd911b7d7a3ecf359d
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spelling	oai:doaj.org-article:8aa6e4727d4c43fd911b7d7a3ecf359d2021-12-02T15:06:01ZNeuromodulatory circuit effects on Drosophila feeding behaviour and metabolism10.1038/s41598-017-08466-02045-2322https://doaj.org/article/8aa6e4727d4c43fd911b7d7a3ecf359d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08466-0https://doaj.org/toc/2045-2322Abstract Animals have evolved to maintain homeostasis in a changing external environment by adapting their internal metabolism and feeding behaviour. Metabolism and behaviour are coordinated by neuromodulation; a number of the implicated neuromodulatory systems are homologous between mammals and the vinegar fly, an important neurogenetic model. We investigated whether silencing fly neuromodulatory networks would elicit coordinated changes in feeding, behavioural activity and metabolism. We employed transgenic lines that allowed us to inhibit broad cellular sets of the dopaminergic, serotonergic, octopaminergic, tyraminergic and neuropeptide F systems. The genetically-manipulated animals were assessed for changes in their overt behavioural responses and metabolism by monitoring eleven parameters: activity; climbing ability; individual feeding; group feeding; food discovery; both fed and starved respiration; fed and starved lipid content; and fed/starved body weight. The results from these 55 experiments indicate that individual neuromodulatory system effects on feeding behaviour, motor activity and metabolism are dissociated.Anders ErikssonMarlena RaczkowskaRapeechai NavawongseDeepak ChoudhuryJames C. StewartYi Ling TangZhiping WangAdam Claridge-ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anders Eriksson Marlena Raczkowska Rapeechai Navawongse Deepak Choudhury James C. Stewart Yi Ling Tang Zhiping Wang Adam Claridge-Chang Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
description	Abstract Animals have evolved to maintain homeostasis in a changing external environment by adapting their internal metabolism and feeding behaviour. Metabolism and behaviour are coordinated by neuromodulation; a number of the implicated neuromodulatory systems are homologous between mammals and the vinegar fly, an important neurogenetic model. We investigated whether silencing fly neuromodulatory networks would elicit coordinated changes in feeding, behavioural activity and metabolism. We employed transgenic lines that allowed us to inhibit broad cellular sets of the dopaminergic, serotonergic, octopaminergic, tyraminergic and neuropeptide F systems. The genetically-manipulated animals were assessed for changes in their overt behavioural responses and metabolism by monitoring eleven parameters: activity; climbing ability; individual feeding; group feeding; food discovery; both fed and starved respiration; fed and starved lipid content; and fed/starved body weight. The results from these 55 experiments indicate that individual neuromodulatory system effects on feeding behaviour, motor activity and metabolism are dissociated.
format	article
author	Anders Eriksson Marlena Raczkowska Rapeechai Navawongse Deepak Choudhury James C. Stewart Yi Ling Tang Zhiping Wang Adam Claridge-Chang
author_facet	Anders Eriksson Marlena Raczkowska Rapeechai Navawongse Deepak Choudhury James C. Stewart Yi Ling Tang Zhiping Wang Adam Claridge-Chang
author_sort	Anders Eriksson
title	Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
title_short	Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
title_full	Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
title_fullStr	Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
title_full_unstemmed	Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism
title_sort	neuromodulatory circuit effects on drosophila feeding behaviour and metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8aa6e4727d4c43fd911b7d7a3ecf359d
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Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism

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